Objective
Cells usually organize themselves into groups before migrating from one place to another in vivo. Most of the time, such groups migrate as three-dimensional entities and contacts between cells are highly dynamic. Unfortunately, such complex behaviours are rarely observed in vitro, where cells migrate as individuals. Therefore, although this collective migration is a general feature during both tissue morphogenesis and tumour metastasis, little is known about the basic cellular mechanisms underlying these processes. In particular the dynamics of cell adhesion and its regulation during the migration process is a question that, until now, has been difficult to tackle using an in vivo approach.
The aim of my project in the lab of the Dr Gilmour is to dissect the precise cell-cell and cell-substrate contacts within a migrating tissue and of the mechanisms that control their formation. The primordium of the zebrafish lateral line (LLp) is such a three dimensional migrating tissue, that has several advantages for this study including experimental accessibility, genetic tractability and excellent imaging potential. During its migration, the LLp becomes subdivided into 7 to 9 groups of cells, which prefigure the neuromasts, the future sensory organs, regularly spaced under the skin. Thus, the LLp undergoes very dynamic cell adhesion remodelling during migration.
Taking advantage of the multidisciplinary scientific environment of the EMBL, I propose to use a number of approach including forward and reverse genetic analysis, high resolution in vivo imaging and mathematic modelling to:
(1) Characterize the cell-cell contacts that shape the primordium during its morphogenesis
(2) Dissect the mechanisms that enable cells to rapidly create and dissolve contacts during such a collective migration
(3) Identify new molecules involved in the dynamic regulation of cell adhesion during the morphogenesis of the lateral line
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
HEIDELBERG
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.