Objectif
Embryonic development is a highly controlled process where biochemical networks are constantly challenged by environmental cues. In a growing embryo, cells grow, divide, migrate, differentiate or arrange to form structures in a mechanically active environment where they can physically alter their environment and react to these changes. It is unclear how do biological systems sense their physical environment in a whole embryo and how positional information is linked with mechanical and geometrical constraints of a growing system. To date, the experimental data addressing these questions are few mainly due to the technical challenges of advanced and fast in vivo imaging required to analyze these physical changes. This project focus in addressing the genetics and epigenetics of biological flows during embryogenesis of zebrafish by using newly developed imaging methods and genetics. In particular, we will address the role of blood flow during cardiovascular development.
Champ scientifique
Appel à propositions
FP7-PEOPLE-2009-RG
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Régime de financement
MC-IRG - International Re-integration Grants (IRG)Coordinateur
67404 Illkirch Graffenstaden
France