Identification and screen of RNA Editing in the Human Genome

Información del proyecto

GENEDISCREEN

Identificador del acuerdo de subvención: 256593

Proyecto cerrado

Fecha de inicio 1 Enero 2011

Fecha de finalización 31 Diciembre 2014

Financiado con arreglo a

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Coste total € 100 000,00

Aportación de la UE € 100 000,00

Coordinado por

BAR ILAN UNIVERSITY
Israel

Objetivo

With the exception of infrequent random mutations (and immune cell receptors), it is widely believed that the genomic content should be fixed in an organism throughout its body and its lifespan. It is therefore clear why the discovery of proteins that can edit the RNA have generated much interest. However, only very few targets have been discover so far. I have recently made important progress in this area by developing novel methods to model and detect RNA editing in mammals. Using a combination of computational approaches and next generation sequencing based technology, I am able, for the first time, to perform large-scale comprehensive screen and sketch the “editosome” fingerprints. As an independent investigator, I will use the padlock probes technology followed by next generation sequencing to associate different diseases with altered editing levels and investigate the impact of RNA editing on genome evolution and development. To achieve these aims, my lab will use a combination of molecular biology and computational approaches. . It is my expectation that these studies will provide fundamental new insights into the mechanism of RNA editing and their role in human biology, within a timeframe of several years.

Ámbito científico (EuroSciVoc)

CORDIS clasifica los proyectos con EuroSciVoc, una taxonomía plurilingüe de ámbitos científicos, mediante un proceso semiautomático basado en técnicas de procesamiento del lenguaje natural. Véase: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

• ciencias médicas y de la salud › medicina básica › inmunología
• ciencias naturales › ciencias biológicas › genética › ARN
• ciencias naturales › ciencias biológicas › zoología › mamalogía
• ciencias naturales › ciencias biológicas › genética › genoma
• ciencias naturales › ciencias biológicas › biología molecular

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Programa(s)

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Tema(s)

• FP7-PEOPLE-2009-RG - Marie Curie Action: "Reintegration Grants"

Convocatoria de propuestas

FP7-PEOPLE-2009-RG
Consulte otros proyectos de esta convocatoria

Régimen de financiación

MC-IRG - International Re-integration Grants (IRG)

Coordinador

BAR ILAN UNIVERSITY

• Aportación de la UE: € 100 000,00
• Dirección: BAR ILAN UNIVERSITY CAMPUS ; 52900 Ramat Gan ; Israel
• Tipo de actividad: Higher or Secondary Education Establishments
• Coste total: Sin datos