Objective Synthesizing organic molecules in high purity with designed properties is of utmost importance for pharmaceutical applications and material- and polymer sciences including the efficient production of enantiopure compounds and the compliance with ecological concerns and sustainability. The efficiency of all reaction classes has improved over the past decades. However, the basic principle and execution did not change: The target molecule is disconnected into donor and acceptor synthons and appropriate functional groups need to be introduced and adjusted to carry out the envisioned coupling. These additional steps decrease the yield and efficiency, are costly in time, resources and produce waste. The introduction of new functionalities by direct C-H or C-C bond activation is a unique and highly appealing strategy. The range of substrates is virtually unlimited, including hydrocarbons, small molecules and polymers. Such dream reactions avoid any pre-functionalization, shorten synthetic routes, make unsought disconnections possible and allow for a more efficient usage of our dwindling resources. Despite recent progress in the activations of inert bonds, narrow scopes, poor reactivities and harsh conditions hamper most general practical applications. Especially, enantioselective activations are a longstanding challenge. The outlined project seeks to address these issues by the development and exploitation of new catalytic enantioselective C-H and C-C functionalizations of broadly available organic substrates, using chiral Rh- and Pd- catalysts, additionally supported by automated screening and computational techniques. These reactions will be then applied in the streamlined synthesis of pharmaceutically relevant scaffolds and of compounds for organic electronics. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsnatural scienceschemical sciencesorganic chemistryhydrocarbonsnatural scienceschemical sciencespolymer sciencesnatural scienceschemical sciencescatalysis Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) ERC-SG-PE5 - ERC Starting Grant - Materials and Synthesis Call for proposal ERC-2010-StG_20091028 See other projects for this call Funding Scheme ERC-SG - ERC Starting Grant Host institution ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE EU contribution € 1 499 500,00 Address BATIMENT CE 3316 STATION 1 1015 Lausanne Switzerland See on map Region Schweiz/Suisse/Svizzera Région lémanique Vaud Activity type Higher or Secondary Education Establishments Administrative Contact Caroline Vandevyver (Dr.) Principal investigator Nicolai Cramer (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Beneficiaries (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Switzerland EU contribution € 1 499 500,00 Address BATIMENT CE 3316 STATION 1 1015 Lausanne See on map Region Schweiz/Suisse/Svizzera Région lémanique Vaud Activity type Higher or Secondary Education Establishments Administrative Contact Caroline Vandevyver (Dr.) Principal investigator Nicolai Cramer (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data