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PREvention of Late Stent Thrombosis by an Interdisciplinary Global European effort

Objective

According to the European Society of Cardiology there has been an increase in the life expectancy at the age of 65 of the European population from 15.0 to 17.0 years in the years since 1980. In the elderly, up to 50% of deaths are caused by cardiovascular diseases, the majority accounted for by coronary artery disease. The most effective treatment for obstructive coronary disease is percutaneous intervention with coronary stenting and fuelled by the increasing disease burden there has been a rapid increase in the number of percutaneous coronary intervention procedures in Europe from 184,000 in 1992 to 885,000 in 2004. If the rate of progression remains constant, the projected number of coronary intervention procedures per annum will be about 1.5 million by 2010, with a stenting rate of close to 100%. The principal safety issue with current coronary stenting procedures is late stent thrombosis which, with a case mortality rate approaching 50%, makes this problem a very significant European health issue.
The PRESTIGE project will result in significant improvement in prediction and prevention of late stent thrombosis by providing novel strategies that causally impede incident events without increasing the overall risk of bleeding. These goals will be achieved by a multidisciplinary consortium formed by world-leading EU-based specialists covering the requisite scientific skills and experience.
Since the first drug-eluting stent was introduced in 2002 the growth of this sector has been explosive. Forecasts predicted the potential for this market segment to exceed €4.6 billion by 2009. The economic impact of this very ambitious project will be to provide the European health industries with novel stent products and new imaging technologies to identify patients at-risk, as well as amended European treatment guidelines. The social impact will be, amongst others, a tremendous cost reduction for the public and private health insurance systems all over Europe.

Call for proposal

FP7-HEALTH-2010-single-stage
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

DEUTSCHES HERZZENTRUM MUNCHEN
Address
Lazarettstrasse 36
80636 Munich
Germany
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
EU contribution
€ 1 182 400
Administrative Contact
Per Larsen (Mr.)

Participants (14)

AZIENDA OSPEDALIERA PAPA GIOVANNI XXIII
Italy
EU contribution
€ 454 210
Address
Piazza Oms 1
24127 Bergamo
Activity type
Other
Administrative Contact
Giulio Guagliumi (Dr.)
SAMODZIELNY PUBLICZNY ZAKLAD OPIEKI ZDROWOTNEJ SZPITAL UNIWERSYTECKI W KRAKOWIE
Poland
EU contribution
€ 58 200
Address
Ul. Kopernika 36
31 501 Krakow
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Dariusz Dudek (Prof.)
STICHTING SINT ANTONIUS ZIEKENHUIS
Netherlands
EU contribution
€ 371 620
Address
Koekoekslaan 1
3435 CM Nieuwegein
Activity type
Research Organisations
Administrative Contact
Jurrien Maria Ten Berg (Dr.)
UNIVERSITY OF LEICESTER
United Kingdom
EU contribution
€ 669 364
Address
University Road
LE1 7RH Leicester
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Bikramjeet Singh (Mr.)
BENEDIKT-KREUTZ REHABILITATIONSZENTRUM FUER HERZ- UND KREISLAUFKRANKE BAD KROZINGEN EV

Participation ended

Germany
EU contribution
€ 121 200
Address
Suedring 15
79189 Bad Krozingen
Activity type
Research Organisations
Administrative Contact
Christian Valina (Dr.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 990 356
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Dina Falkenreck (Ms.)
RIGAS TEHNISKA UNIVERSITATE
Latvia
EU contribution
€ 100 755
Address
Kalku Iela 1
1658 Riga
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Garry Kerch (Dr.)
KITOZYME SA
Belgium
EU contribution
€ 110 400
Address
Rue Haute Claire Parc Industriel 4
4040 Herstal
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Marie Hobe (Ms.)
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
EU contribution
€ 346 466,50
Address
Ingolstadter Landstrasse 1
85764 Neuherberg
Activity type
Research Organisations
Administrative Contact
Juergen Ertel (Dr.)
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 711 270
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Walter Desmet (Prof.)
SERVICIO MADRILENO DE SALUD
Spain
EU contribution
€ 121 440
Address
Plaza Carlos Trias Bertran 7
28020 Madrid
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Fernando Alfonso (Dr.)
BIOTRONIK SE & CO. KG
Germany
EU contribution
€ 380 980
Address
Woermannkehre 1
12359 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Alexander Rzany (Dr.)
NEOPLAS GMBH
Germany
EU contribution
€ 360 980
Address
Walther Rathenau Strasse 49A
17489 Greifswald
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Renate Schönebeck (Ms.)
UNIVERSITATS-HERZZENTRUM FREIBURG-BAD KROZINGEN GMBH
Germany
Address
Sudring 15
79189 Bad Krozingen
Activity type
Research Organisations
Administrative Contact
Gerhard Henninger (Mr.)