Objective Health care practitioners face daily questions and make choices regarding the effectiveness and quality of several health technologies (e.g. alternative interventions). On this regard they usually consider meta-analysis; the statistical synthesis of results from relevant experiments. The main drawback of the current state of the art is that meta-analysis focuses on comparing only two alternatives. However, clinicians and scientists need to know the relative ranking of a set of alternative options and not only whether option A is better than B. There is an urgent need to establish and disseminate a robust framework for selecting among many treatment options, possibly after taking into account environmental and genetic interactions. The goal of the proposed project is to provide this by establishing and disseminating a revolutionary evidence synthesis toolkit. Its main methodological vehicle is a flexible statistical framework using Bayesian techniques for multiple-treatments meta-analysis. This will enable the relative ranking of all alternative health care options, will allow comprehensive use of all available data, will improve precision and confidence in the conclusions and will answer methodological questions related to bias. Once established in clinical epidemiology, the tool will be extended to genetic epidemiology to account for multiple genetic markers, environmental factors and effects of treatments. Based on ongoing collaborations with teams undertaking applied health care research I plan to evaluate the new tool empirically in real-life health care problems such as ranking the pharmacological treatments for osteoarthritis, indicating the best treatments for multiple sclerosis and ranking the vaccines for influenza. Fields of science medical and health scienceshealth sciencespublic healthepidemiologymedical and health scienceshealth sciencesinfectious diseasesRNA virusesinfluenzamedical and health sciencesbasic medicineneurologymultiple sclerosismedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) ERC-SG-LS7 - Applied life sciences, biotechnology and bioengineering: agricultural, animal, fishery, forestry/food sciences; biotechnology, chemical biology, genetic engineering, synthetic biology, industrial biosciences; environmental biotechnology. Call for proposal ERC-2010-StG_20091118 See other projects for this call Funding Scheme ERC-SG - ERC Starting Grant Host institution PANEPISTIMIO IOANNINON EU contribution € 592 500,00 Address PANEPISTEMIOYPOLE PANEPISTEMIO IOANNINON 45110 Ioannina Greece See on map Region Βόρεια Ελλάδα Ήπειρος Ιωάννινα Activity type Higher or Secondary Education Establishments Administrative Contact Georgios Detsikas (Mr.) Principal investigator Georgia Salanti (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Beneficiaries (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all PANEPISTIMIO IOANNINON Greece EU contribution € 592 500,00 Address PANEPISTEMIOYPOLE PANEPISTEMIO IOANNINON 45110 Ioannina See on map Region Βόρεια Ελλάδα Ήπειρος Ιωάννινα Activity type Higher or Secondary Education Establishments Administrative Contact Georgios Detsikas (Mr.) Principal investigator Georgia Salanti (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
