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More Medicines for Tuberculosis

Objective

The More Medicines for Tuberculosis (MM4TB) consortium evolved from the highly successful FP6 project, New Medicines for TB (NM4TB), that delivered a candidate drug for clinical development two years ahead of schedule. Building on these firm foundations and exploiting its proprietary pharmacophores, MM4TB will continue to develop new drugs for TB treatment. An integrated approach will be implemented by a multidisciplinary team that combines some of Europe's leading academic TB researchers with two major pharmaceutical companies and four SMEs, all strongly committed to the discovery of anti-infective agents. MM4TB will use a tripartite screening strategy to discover new hits in libraries of natural products and synthetic compounds, while concentrating on both classical and innovative targets that have been pharmacologically validated. Whole cell screens will be conducted against Mycobacterium tuberculosis using in vitro and ex vivo models for active growth, latency and intracellular infection. Hits that are positive in two or more of these models will then be used for target identification using functional genomics technologies including whole genome sequencing and genetic complementation of resistant mutants, yeast three hybrid, click chemistry and proteomics. Targets thus selected will enter assay development, structure determination, fragment-based and rational drug design programs; functionally related targets will be found using metabolic pathway reconstruction. Innovative techniques, based on microfluidics and array platforms, will be used for hit ranking, determining rates of cidality and confirming mechanism of action. Medicinal chemistry will convert leads to molecules with drug-like properties for evaluation of efficacy in different animal models and late preclinical testing.

Field of science

  • /natural sciences/biological sciences/genetics and heredity/genome
  • /medical and health sciences/basic medicine/medicinal chemistry
  • /medical and health sciences/clinical medicine/pneumology/tuberculosis

Call for proposal

FP7-HEALTH-2010-single-stage
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Address
Batiment Ce 3316 Station 1
1015 Lausanne
Switzerland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 062 998
Administrative Contact
Stewart Cole (Prof.)

Participants (26)

AstraZeneca India Pvt Ltd.

Participation ended

India
EU contribution
€ 416 372,10
Address
'Avishkar', Bellary Road
560024 Bangalore
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Tanjore Balganesh (Dr.)
UPPSALA UNIVERSITET
Sweden
EU contribution
€ 730 000
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Leif Kirsebom (Prof.)
UNIVERSITA DEGLI STUDI DI PAVIA
Italy
EU contribution
€ 648 000
Address
Strada Nuova 65
27100 Pavia
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sofia Baggini (Dr.)
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 542 461,60
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Renata Schaeffer (Ms.)
QUEEN MARY UNIVERSITY OF LONDON

Participation ended

United Kingdom
EU contribution
€ 217 650,95
Address
327 Mile End Road
E1 4NS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tanya Szendeffy (Prof.)
INSTITUT PASTEUR
France
EU contribution
€ 492 920,33
Address
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
Activity type
Research Organisations
Administrative Contact
Nadia Khelef (Ms.)
A.N. BAKH INSTITUTE OF BIOCHEMISTRY OF THE RUSSIAN ACADEMY OF SCIENCES
Russia
EU contribution
€ 531 999,96
Address
Leninsky Prospect 33
119071 Moscow
Activity type
Research Organisations
Administrative Contact
Vadim Makarov (Dr.)
UNIVERSITA DEGLI STUDI DI PADOVA
Italy
EU contribution
€ 374 992,41
Address
Via 8 Febbraio 2
35122 Padova
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Giovanni Abatangelo (Prof.)
UNIVERZITA KOMENSKEHO V BRATISLAVE
Slovakia
EU contribution
€ 424 843,44
Address
Safarikovo Nam 6
814 99 Bratislava
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Beata Rajnakova (Dr.)
VICHEM CHEMIE KUTATO KFT
Hungary
EU contribution
€ 439 997,14
Address
Hermann Otto Utca 15
1022 Budapest
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
György Kéri (Prof.)
JOHN INNES CENTRE
United Kingdom
EU contribution
€ 400 000
Address
Norwich Research Park Colney
NR4 7UH Norwich
Activity type
Research Organisations
Administrative Contact
Mary Anderson (Dr.)
INDIAN INSTITUTE OF SCIENCE
India
EU contribution
€ 162 000
Address
Cross Malleshwaram 18
560012 Bangalore
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Valakunja Nagaraja (Prof.)
CELLWORKS RESEARCH INDIA PRIVATE LIMITED
India
EU contribution
€ 250 000
Address
3Rd Floor, West Wing, Neil Rao Tower, Epip Whitefield 118, Road 3
560066 Bangalore
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Anand Anandkumar (Dr.)
UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO
Italy
EU contribution
€ 386 800
Address
Duomo 6
13100 Vercelli
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Carlo Muzio (Dr.)
COLLABORATIVE DRUG DISCOVERY INC CORPORATION
United States
EU contribution
€ 270 000
Address
Bayshore Highway 1633 Suite 342
94010 Burlingame Ca
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Sean Ekins (Dr.)
UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA
Spain
EU contribution
€ 260 000
Address
Barrio Sarriena S N
48940 Leioa
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Charo Sánchez (Ms.)
TYDOCK PHARMA S.r.l
Italy
EU contribution
€ 499 800
Address
Strada Gherbella 294/B
41126 Modena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Alberto Venturelli (Dr.)
UNIVERSIDAD DE ZARAGOZA
Spain
EU contribution
€ 260 000
Address
Calle Pedro Cerbuna 12
50009 Zaragoza
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jose A. Ainsa (Dr.)
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
EU contribution
€ 450 000
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Karl-Heinz Altmann (Prof.)
ALERE TECHNOLOGIES GMBH
Germany
EU contribution
€ 150 000
Address
Lobstedter Str 103 105
07749 Jena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Albert Hinnen (Dr.)
SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT
France
EU contribution
€ 384 997,83
Address
Pierre Brossolette 1
91380 Chilly Mazarin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Frederic Galli (Dr.)
UNIVERSITY OF CAPE TOWN
South Africa
EU contribution
€ 248 750,03
Address
Private Bag X3
7701 Rondebosch
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Roger Wallace (Dr.)
SCIPROM SARL

Participation ended

Switzerland
EU contribution
€ 150 515,62
Address
Rue Du Centre 70
1025 Saint Sulpice
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Iain Old (Dr.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 447 802,75
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Virginie Chameroy (Ms.)
FONDATION INNOVATIVE MEDICINES FOR TUBERCULOSIS (IM4TB)
Switzerland
EU contribution
€ 455 147,67
Address
Epfl Innovation Park Batiment I
1015 Lausanne
Activity type
Other
Administrative Contact
Iain Old (Dr.)
SANOFI-AVENTIS DEUTSCHLAND GMBH
Germany
EU contribution
€ 215 002,17
Address
Bruningstrasse 50
65929 Frankfurt Am Main
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Olaf Boesch (Mr.)