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More Medicines for Tuberculosis

Obiettivo

The More Medicines for Tuberculosis (MM4TB) consortium evolved from the highly successful FP6 project, New Medicines for TB (NM4TB), that delivered a candidate drug for clinical development two years ahead of schedule. Building on these firm foundations and exploiting its proprietary pharmacophores, MM4TB will continue to develop new drugs for TB treatment. An integrated approach will be implemented by a multidisciplinary team that combines some of Europe's leading academic TB researchers with two major pharmaceutical companies and four SMEs, all strongly committed to the discovery of anti-infective agents. MM4TB will use a tripartite screening strategy to discover new hits in libraries of natural products and synthetic compounds, while concentrating on both classical and innovative targets that have been pharmacologically validated. Whole cell screens will be conducted against Mycobacterium tuberculosis using in vitro and ex vivo models for active growth, latency and intracellular infection. Hits that are positive in two or more of these models will then be used for target identification using functional genomics technologies including whole genome sequencing and genetic complementation of resistant mutants, yeast three hybrid, click chemistry and proteomics. Targets thus selected will enter assay development, structure determination, fragment-based and rational drug design programs; functionally related targets will be found using metabolic pathway reconstruction. Innovative techniques, based on microfluidics and array platforms, will be used for hit ranking, determining rates of cidality and confirming mechanism of action. Medicinal chemistry will convert leads to molecules with drug-like properties for evaluation of efficacy in different animal models and late preclinical testing.

Invito a presentare proposte

FP7-HEALTH-2010-single-stage
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Coordinatore

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Indirizzo
Batiment Ce 3316 Station 1
1015 Lausanne
Svizzera
Tipo di attività
Higher or Secondary Education Establishments
Contributo UE
€ 2 062 998
Contatto amministrativo
Stewart Cole (Prof.)

Partecipanti (26)

AstraZeneca India Pvt Ltd.

Partecipazione conclusa

India
Contributo UE
€ 416 372,10
Indirizzo
'Avishkar', Bellary Road
560024 Bangalore
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Tanjore Balganesh (Dr.)
UPPSALA UNIVERSITET
Svezia
Contributo UE
€ 730 000
Indirizzo
Von Kraemers Alle 4
751 05 Uppsala
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Leif Kirsebom (Prof.)
UNIVERSITA DEGLI STUDI DI PAVIA
Italia
Contributo UE
€ 648 000
Indirizzo
Strada Nuova 65
27100 Pavia
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Sofia Baggini (Dr.)
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Contributo UE
€ 542 461,60
Indirizzo
Trinity Lane The Old Schools
CB2 1TN Cambridge
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Renata Schaeffer (Ms.)
QUEEN MARY UNIVERSITY OF LONDON

Partecipazione conclusa

United Kingdom
Contributo UE
€ 217 650,95
Indirizzo
327 Mile End Road
E1 4NS London
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Tanya Szendeffy (Prof.)
INSTITUT PASTEUR
Francia
Contributo UE
€ 492 920,33
Indirizzo
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
Tipo di attività
Research Organisations
Contatto amministrativo
Nadia Khelef (Ms.)
A.N. BAKH INSTITUTE OF BIOCHEMISTRY OF THE RUSSIAN ACADEMY OF SCIENCES
Russia
Contributo UE
€ 531 999,96
Indirizzo
Leninsky Prospect 33
119071 Moscow
Tipo di attività
Research Organisations
Contatto amministrativo
Vadim Makarov (Dr.)
UNIVERSITA DEGLI STUDI DI PADOVA
Italia
Contributo UE
€ 374 992,41
Indirizzo
Via 8 Febbraio 2
35122 Padova
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Giovanni Abatangelo (Prof.)
UNIVERZITA KOMENSKEHO V BRATISLAVE
Slovacchia
Contributo UE
€ 424 843,44
Indirizzo
Safarikovo Nam 6
814 99 Bratislava
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Beata Rajnakova (Dr.)
VICHEM CHEMIE KUTATO KFT
Ungheria
Contributo UE
€ 439 997,14
Indirizzo
Hermann Otto Utca 15
1022 Budapest
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
György Kéri (Prof.)
JOHN INNES CENTRE
United Kingdom
Contributo UE
€ 400 000
Indirizzo
Norwich Research Park Colney
NR4 7UH Norwich
Tipo di attività
Research Organisations
Contatto amministrativo
Mary Anderson (Dr.)
INDIAN INSTITUTE OF SCIENCE
India
Contributo UE
€ 162 000
Indirizzo
Cross Malleshwaram 18
560012 Bangalore
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Valakunja Nagaraja (Prof.)
CELLWORKS RESEARCH INDIA PRIVATE LIMITED
India
Contributo UE
€ 250 000
Indirizzo
3Rd Floor, West Wing, Neil Rao Tower, Epip Whitefield 118, Road 3
560066 Bangalore
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Anand Anandkumar (Dr.)
UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO
Italia
Contributo UE
€ 386 800
Indirizzo
Duomo 6
13100 Vercelli
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Carlo Muzio (Dr.)
COLLABORATIVE DRUG DISCOVERY INC CORPORATION
Stati Uniti
Contributo UE
€ 270 000
Indirizzo
Bayshore Highway 1633 Suite 342
94010 Burlingame Ca
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Sean Ekins (Dr.)
UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA
Spagna
Contributo UE
€ 260 000
Indirizzo
Barrio Sarriena S N
48940 Leioa
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Charo Sánchez (Ms.)
TYDOCK PHARMA S.r.l
Italia
Contributo UE
€ 499 800
Indirizzo
Strada Gherbella 294/B
41126 Modena
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Alberto Venturelli (Dr.)
UNIVERSIDAD DE ZARAGOZA
Spagna
Contributo UE
€ 260 000
Indirizzo
Calle Pedro Cerbuna 12
50009 Zaragoza
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Jose A. Ainsa (Dr.)
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Svizzera
Contributo UE
€ 450 000
Indirizzo
Raemistrasse 101
8092 Zuerich
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Karl-Heinz Altmann (Prof.)
ALERE TECHNOLOGIES GMBH
Germania
Contributo UE
€ 150 000
Indirizzo
Lobstedter Str 103 105
07749 Jena
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Albert Hinnen (Dr.)
SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT
Francia
Contributo UE
€ 384 997,83
Indirizzo
Pierre Brossolette 1
91380 Chilly Mazarin
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Frederic Galli (Dr.)
UNIVERSITY OF CAPE TOWN
Sud Africa
Contributo UE
€ 248 750,03
Indirizzo
Private Bag X3
7701 Rondebosch
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Roger Wallace (Dr.)
SCIPROM SARL

Partecipazione conclusa

Svizzera
Contributo UE
€ 150 515,62
Indirizzo
Rue Du Centre 70
1025 Saint Sulpice
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Iain Old (Dr.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Francia
Contributo UE
€ 447 802,75
Indirizzo
Rue De Tolbiac 101
75654 Paris
Tipo di attività
Research Organisations
Contatto amministrativo
Virginie Chameroy (Ms.)
FONDATION INNOVATIVE MEDICINES FOR TUBERCULOSIS (IM4TB)
Svizzera
Contributo UE
€ 455 147,67
Indirizzo
Epfl Innovation Park Batiment I
1015 Lausanne
Tipo di attività
Other
Contatto amministrativo
Iain Old (Dr.)
SANOFI-AVENTIS DEUTSCHLAND GMBH
Germania
Contributo UE
€ 215 002,17
Indirizzo
Bruningstrasse 50
65929 Frankfurt Am Main
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Olaf Boesch (Mr.)