A Modular Nanosystems Platform for Advanced Cancer Management: Nano-vehicles; Tumor Targeting and Penetration Agents; Molecular Imaging, Degradome based Therapy

Informazioni relative al progetto

SAVEME

ID dell’accordo di sovvenzione: 263307

Progetto chiuso

Data di avvio 1 Marzo 2011

Data di completamento 28 Febbraio 2015

Finanziato da

• Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies

Costo totale € 13 809 085,64

Contributo UE € 10 500 000,00

Coordinato da

TEL AVIV UNIVERSITY
Israel

Obiettivo

SaveMe project will address current urgent needs for pancreatic cancer diagnosis and treatment by exploiting partners’ expertise and most recent research achievements for the design and development of novel modular nanosystems platform integrating new functionalized nano-core particles and active agents. The modular platform will enable the design of diverse active nanosystems per diagnostic or therapeutic application as defined by their active agent compositions. For diagnostics, superior tracers will be developed for molecular MR/PET and gamma camera imaging, enabling efficient diagnosis and guided surgery respectively. Novel functionalized nano-core systems will be conjugated with semi-confluent active shell layer. Three types of shell layers will be design: (1) novel iron oxide nanoparticles as advanced MRI contrast agents and/or (2) DOTA complexes for MRI (with Gd3+), or PET (with Ga-68), or gamma camera (with Ga-69); (3) Integrating within one tracer both iron oxide nanoparticles and DOTA-Ga-68 complexes for a sequential or simultaneous MR/PET imaging. For therapeutics, active nanosystems will be developed to deliver (1) therapeutic siRNAs or (2) anti-MP-inhibitory-scFVs. These non-classic anti-tumor drugs will be designed based on an extensive tumor degradome analysis for combining blockage of selective matrix MPs, thus preventing basic invasive and metastasis steps, with siRNA based neutralization of secondary molecular effects induced by the specific protease inhibition. Individualized degradome analysis will be developed for potential profiling of anti-MP and siRNAs based therapy per patient. To facilitate the above diagnostics and therapeutic effects, advanced tumor targeting and penetration active agents will be linked to nano-core functionalized groups, including a biocompatible PEG layer linked to tumor selective MMP substrate molecules and highly safe and potent novel somatostatin analogue peptides targeting SSTR overexpression.

Campo scientifico

• medical and health sciences › clinical medicine › surgery
• engineering and technology › electrical engineering, electronic engineering, information engineering › electronic engineering › sensors › optical sensors
• medical and health sciences › clinical medicine › radiology › nuclear medicine
• engineering and technology › nanotechnology › nano-materials
• medical and health sciences › clinical medicine › oncology › pancreatic cancer

Programma(i)

• FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies

Argomento(i)

• NMP-2010-4.0-1 - Development of nanotechnology-based systems for detection, diagnosis and therapy for cancer

Invito a presentare proposte

FP7-NMP-2010-LARGE-4
Vedi altri progetti per questo bando

Meccanismo di finanziamento

CP-IP - Large-scale integrating project

Coordinatore

TEL AVIV UNIVERSITY

• Contributo UE: € 842 728,00
• Indirizzo: RAMAT AVIV ; 69978 Tel Aviv ; Israele
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Lea Pais (Ms.)
• Costo totale: Nessun dato

Partecipanti (22)

VEREIN ZUR FOERDERUNG DER WISSENSCHAFTLICHEN FORSCHUNG AM WILHELMINENSPITAL DER STADT WIEN

Austria

• Contributo UE: € 229 064,00
• Indirizzo: Montleartstrasse 37 ; 1160 WIEN
• Tipo di attività: Research Organisations
• Contatto amministrativo: Peter Knoll (Prof.)
• Costo totale: Nessun dato

UNIVERSITATSKLINIKUM HEIDELBERG

Germania

• Contributo UE: € 967 806,00
• Indirizzo: IM NEUENHEIMER FELD 672 ; 69120 Heidelberg
• Regione: Baden-Württemberg › Karlsruhe › Heidelberg, Stadtkreis
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Thorsten Brietz
• Costo totale: Nessun dato

BAR ILAN UNIVERSITY

Israele

• Contributo UE: € 1 123 440,00
• Indirizzo: BAR ILAN UNIVERSITY CAMPUS ; 52900 Ramat Gan
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Billy Mikanovsky (Ms.)
• Costo totale: Nessun dato

ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA

Italia

• Contributo UE: € 461 600,00
• Indirizzo: VIA ZAMBONI 33 ; 40126 Bologna
• Regione: Nord-Est › Emilia-Romagna › Bologna
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Verdania Bandini (Ms.)
• Costo totale: Nessun dato

JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN

Germania

• Contributo UE: € 252 748,00
• Indirizzo: THEODOR W ADORNO PLATZ 1 ; 60323 Frankfurt Am Main
• Regione: Hessen › Darmstadt › Frankfurt am Main, Kreisfreie Stadt
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Joerg Kreuter (Prof.)
• Costo totale: Nessun dato

RESEARCH AND PRODUCTION COMPLEX NANOSYSTEM LLC

Russia

• Contributo UE: € 165 200,00
• Indirizzo: 7TH KOZHUKHOVSKAYA 20 ; 115193 MOSKVA
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Svetlana Gelperina (Dr.)
• Costo totale: Nessun dato

FUNDACION CIDETEC

Spagna

• Contributo UE: € 553 020,00
• Indirizzo: PASEO MIRAMON 196 PARQUE TECNOLOGICO DE MIRAMON ; 20014 San Sebastian
• Regione: Noreste › País Vasco › Gipuzkoa
• Tipo di attività: Research Organisations
• Contatto amministrativo: Iraida Loinaz (Dr.)
• Costo totale: Nessun dato

ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE

Spagna

• Contributo UE: € 584 000,00
• Indirizzo: PASEO MIRAMON 182, PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C ; 20009 San Sebastian
• Regione: Noreste › País Vasco › Gipuzkoa
• Tipo di attività: Research Organisations
• Contatto amministrativo: Alfonso Egaña (Mr.)
• Costo totale: Nessun dato

COLOROBBIA ITALIA SPA

Partecipazione conclusa

Italia

• Contributo UE: € 56 451,00
• Indirizzo: VIA PIETRAMARINA 53 ; 50059 SOVIGLIANA VINCI
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Poala Terreni (Ms.)
• Costo totale: Nessun dato

MEDICAL RESEARCH INFRASTRUCTURE DEVELOPMENT AND HEALTH SERVICES FUND BY THE SHEBA MEDICAL CENTER

Israele

• Contributo UE: € 873 865,00
• Indirizzo: TEL HASHOMER SHEBA MEDICAL CENTER ; 52621 Ramat Gan
• Tipo di attività: Research Organisations
• Contatto amministrativo: Shlomo Noy (Prof.)
• Costo totale: Nessun dato

UNIVERSITY OF EAST ANGLIA

Regno Unito

• Contributo UE: € 504 200,00
• Indirizzo: EARLHAM ROAD ; NR4 7TJ Norwich
• Regione: East of England › East Anglia › Norwich and East Norfolk
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Alan Walker (Dr.)
• Costo totale: Nessun dato

KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN

Germania

• Contributo UE: € 630 670,00
• Indirizzo: ISMANINGER STRASSE 22 ; 81675 Muenchen
• Regione: Bayern › Oberbayern › München, Kreisfreie Stadt
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Renate Rädlein
• Costo totale: Nessun dato

KATHOLIEKE UNIVERSITEIT LEUVEN

Belgio

• Contributo UE: € 470 236,00
• Indirizzo: OUDE MARKT 13 ; 3000 Leuven
• Regione: Vlaams Gewest › Prov. Vlaams-Brabant › Arr. Leuven
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Elke Lammertyn (Dr.)
• Costo totale: Nessun dato

WEIZMANN INSTITUTE OF SCIENCE

Israele

• Contributo UE: € 601 107,00
• Indirizzo: HERZL STREET 234 ; 7610001 Rehovot
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Talia Tzahor (Ms.)
• Costo totale: Nessun dato

SHEMYAKIN AND OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY - RUSSIAN ACADEMY OF SCIENCE

Russia

• Contributo UE: € 560 636,00
• Indirizzo: UL. MIKLUKHO MAKLAYA 16/10 ; 117997 MOSCOW
• Tipo di attività: Higher or Secondary Education Establishments
• Contatto amministrativo: Sergey Zavriev (Prof.)
• Costo totale: Nessun dato

nHance Technologies Limited

Partecipazione conclusa

Regno Unito

• Contributo UE: € 359 023,00
• Indirizzo: 5 BRUTON WAY ; W13 0BY London
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Nadipalli Prasad (Dr.)
• Costo totale: Nessun dato

FILARETE SERVIZI SRL

Italia

• Contributo UE: € 356 800,00
• Indirizzo: VIALE ORTLES 22 4 ; 20139 MILANO MI
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Paolo Milani (Prof.)
• Costo totale: Nessun dato

GEMS PET SYSTEMS AKTIEBOLAG

Partecipazione conclusa

Svezia

• Contributo UE: € 40 162,00
• Indirizzo: HUSBYBORG ; 752 28 Uppsala
• Regione: Östra Sverige › Östra Mellansverige › Uppsala län
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Bengt Nielsen (Dr.)
• Costo totale: Nessun dato

OSM-DAN LTD

Israele

• Contributo UE: € 381 640,00
• Indirizzo: 19 PRO NEEMAN YUVAL ST ; 7608665 Rehovot
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Pnina Dan (Dr.)
• Costo totale: Nessun dato

BENCAR AB

Svezia

• Contributo UE: € 338 496,00
• Indirizzo: DAG HAMMARKJOLD VAG 52B ; 75183 UPPSALA
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Bengt Långström (Prof.)
• Costo totale: Nessun dato

ASCEND TECHNOLOGIES LIMITED

Regno Unito

• Contributo UE: € 133 578,00
• Indirizzo: 15-17 CUMBERLAND PLACE ; SO15 2BG SOUTHAMPTON
• Regione: South East (England) › Hampshire and Isle of Wight › Southampton
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Victor Popov (Prof.)
• Costo totale: Nessun dato

COLOROBBIA CONSULTING SRL

Italia

• Contributo UE: € 13 530,00
• Indirizzo: VIA PIETRAMARINA 53 ; 50053 Sovigliana
• Regione: Centro (IT) › Toscana › Firenze
• Tipo di attività: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contatto amministrativo: Laura Niccolai (Dr.)
• Costo totale: Nessun dato