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Content archived on 2024-06-18

High resolution tools to understand the functional role of protein intrinsic disorder

Objective

Recent evidence shows that a large share of proteins gain functional advantages by remaining natively unstructured, either completely or partially, thus challenging well-established concepts in structural biology. In order to characterize the highly dynamical nature of such “intrinsically disordered proteins”, and follow their (possible) reorganization by interacting with partners, new integrated multidisciplinary approaches combining a variety of experimental and computational techniques are needed. Our proposal is focused on NMR spectroscopy, since this technique offers an arsenal of effective tools for the study of the structural and dynamical properties of disordered states of proteins at atomic resolution in systems as complex as whole cells. In order to achieve the full potential of this approach, however, current methods should be further developed and properly interfaced with other complementary techniques. The purpose of our network is thus to establish a framework to train a new generation of young researchers and help them develop the necessary skills to successfully respond to the challenges associated with the elucidation of the functional role of intrinsically disordered protein states. If achieved, this goal will provide us with a more quantitative understanding of the biochemical processes at the basis of life and have a significant impact in biomedical research and in the design of new drugs.

Call for proposal

FP7-PEOPLE-2010-ITN
See other projects for this call

Coordinator

CONSORZIO INTERUNIVERSITARIO RISONANZE MAGNETICHE DI METALLO PROTEINE
EU contribution
€ 580 132,93
Address
PIAZZA DI SAN MARCO 4
50121 FIRENZE
Italy

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Region
Centro (IT) Toscana Firenze
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Isabella Caterina Felli (Prof.)
Links
Total cost
No data

Participants (9)