Objetivo The prediction of biological (and in particular toxicological) impacts has, as its basic pre-requisite, the correct prediction of the sites of action and localization of the nanoparticle in living organisms. We have identified the need for a paradigm shift in modelling these properties for nanoscale objects. The interactions between bare particles and organisms (cells, biological barriers) is radically different in the presence of proteins and lipids derived from the biological environment (the ‘protein corona’). The bare particle characteristic is therefore insufficient to describe the system. Similarly, nanoparticles are trafficked and translocated between sites by active biological processes where traditional ‘equilibrium’ principles for small molecules no longer apply. NanoTransKinetics is firmly based on advanced high quality experimental data on the distribution of nanoparticles in cells, across barriers, and (more limited) in vivo. We frame phenomenological models in a modular manner by abstracting the essential relevant principles of particle-protein (and matrix) interactions, cellular and barrier transport mechanisms of nanoparticles, fitting them to experimental data. More detailed models allow for explicit checking of mechanisms and movements of individual particles into cells and across barriers. Enormous amounts of experimental data are now available to validate the models. A predictive capacity requires only simple input data on particle, corona and similar characteristics. The basis of these claims has been checked in preliminary studies, and a limited number of interactions, particles fluxes (and control parameters) between prescribed sites are sufficient to specify the system at each level of description. Resources (reaching far beyond the program itself) have been mobilised in experimental work in the Partners laboratories, and EU and US collaborations. The output will be predictive tools for use in nanosafety research and regulation and beyond. Ámbito científico natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesbiological sciencesbiochemistrybiomoleculeslipidsengineering and technologynanotechnologynano-materials Programa(s) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Tema(s) NMP.2010.1.3-2 - Modelling toxicity behaviour of engineered nanoparticles Convocatoria de propuestas FP7-NMP-2010-EU-USA Consulte otros proyectos de esta convocatoria Régimen de financiación CP-FP - Small or medium-scale focused research project Coordinador UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN Aportación de la UE € 392 856,00 Dirección BELFIELD 4 Dublin Irlanda Ver en el mapa Región Ireland Eastern and Midland Dublin Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Participantes (2) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Alemania Aportación de la UE € 314 400,00 Dirección GESCHWISTER SCHOLL PLATZ 1 80539 Muenchen Ver en el mapa Región Bayern Oberbayern München, Kreisfreie Stadt Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos UNIVERSITAT DE BARCELONA España Aportación de la UE € 285 757,00 Dirección GRAN VIA DE LES CORTS CATALANES 585 08007 Barcelona Ver en el mapa Región Este Cataluña Barcelona Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
