Objective
Bioresorbable implants are developed for trauma treatment, facial reconstruction and bone defect reconstruction. Historically, most of these devices were made of metal, often requiring a second operation to remove the implant. With resorbable materials this is no longer required and the challenge becomes to tune the resorption rate such that the body can replace the resorbed material with new tissue. The resorption rate can be controlled to some extend by material and geometrical parameters. However, in reality the resorption rate shows a large variation in patients, as there are large differences in the rate of tissue repair amongst patients. For example, in some patients a fractured bone may repair in weeks; in others it may take months.
This illustrates the need for devices of which the resorption rate is not device-related, but can be tuned to the patient's needs. The objective of the current project is to develop devices that can be implanted and which become resorbable only after external stimulation. Hence, this approach is radically different from current practice. The objectives will be achieved by developing technology that enables isolation of the implanted resorbable material (e.g. a bone plate) from the body fluids. When the implant is not required anymore the physician can activate the resorption process of the implant by dissolving the isolation layer using an externally emitted source (e.g. ultrasound or magnetic field stimulation).
Devices that will be developed are specific activation transmitters and resorbable devices that can be activated externally thereby starting the resorption. In the first phase, different technologies are brought together to develop this innovative approach. Subsequently, the technology will be applied to existing products and evaluated using in vitro and animal studies. In the prototyping phase the technology is applied to new products, which are pre-clinically tested using cadaver experiments and large animal models.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology materials engineering coating and films
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
- medical and health sciences medical biotechnology implants
- natural sciences physical sciences acoustics ultrasound
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-NMP-SME-4
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
PO Box 9101 NIJMEGEN
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.