Generation of Striatal Neurons from Mouse and Human Embryonic Stem Cells: its Relevance for Regenerative Medicine in Huntington's Disease and for Studying Striatal Development

Project Information

HESC DIFFERENTIATION

Grant agreement ID: 268248

Project closed

Start date 1 November 2010

End date 31 October 2014

Funded under

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Total cost € 100 000,00

EU contribution € 100 000,00

Coordinated by

UNIVERSITA DEGLI STUDI DI MILANO
Italy

Objective

Huntington’s disease (HD) is an autosomal-dominant, progressive neurodegenerative disorder that usually onsets in midlife. It is characterized by motor, cognitive, and psychiatric symptoms. Once symptomatic, patients are rapidly disabled and require increasing multidisciplinary care. HD is a tremendous burden for medical, social, and family resources. The symptoms and the progression of HD can be linked to its neuropathology, which is characterized by loss of specific neuronal populations in many brain regions. The most important and best studied neuropathology is found in the basal ganglia, in particular a gross atrophy of the striatum. The striatum is characterized by different neuronal populations. Several studies have shown that medium spiny neurons (MSN) are severely affected in HD. MSN are inhibitory projection neurons and are the primary source of striatal projections.Existing medical strategies are available to alleviate some symptoms of HD, including symptomatic therapies (for movements disorders, cognitive impairment, and behavioural manifestations), neuroprotective therapies (anti-glutamatergic drugs), and preventive therapies (for anticipating the clinical onset). Nevertheless, it remains clear that the progressive neurodegenerative process is essentially untreatable medically. For this reason new regenerative therapies that replace neuronal populations and restore function are of great interest and a mandatory research field. This proposal aims at developing new strategies for producing fully functional human striatal neurons from hES with the goal of a future transplantation in HD.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.

• medical and health sciences › medical biotechnology › cells technologies › stem cells
• medical and health sciences › clinical medicine › transplantation

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Programme(s)

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Topic(s)

• FP7-PEOPLE-2009-RG - Marie Curie Action: "Reintegration Grants"

Call for proposal

FP7-PEOPLE-2010-RG
See other projects for this call

Funding Scheme

MC-IRG - International Re-integration Grants (IRG)

Coordinator

UNIVERSITA DEGLI STUDI DI MILANO

• EU contribution: € 100 000,00
• Address: Via Festa Del Perdono 7 ; 20122 Milano ; Italy
• Region: Nord-Ovest › Lombardia › Milano
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Sergio Longo (Mr.)
• Total cost: No data