Objective
Alternative splicing is the process by which multiple mRNA isoforms can be generated from one gene by differential usage of alternative exons in the mature mRNA. It is a major mechanism by which higher vertebrates generate functional complexity of their proteome. Approximately 95% of human genes are alternatively spliced and this process is especially abundant in the nervous system and crucial for proper regulation of neuronal gene expression. Evidence comes from identification of mutations disrupting pre-mRNA sequences, required for alternative splicing, but not for protein coding that cause neurological disease in humans. Moreover, mutations of some RNA binding proteins, with roles in alternative mRNA processing, also result in neuro-developmental disorders and widespread misregulation of alternative splicing. With advancements of high throughput sequencing techniques our knowledge about the kinds of alternative mRNA isoforms and their abundance in different kinds of tissue is rapidly increasing. However, our understanding of the functional consequences of neuron-specific alternative splicing is still very limited. During my postdoctoral studies I have discovered that Hu RNA binding proteins are required for alternative splicing of pre-mRNA targets with important roles in neuronal development and function. I propose to investigate the functions of individual protein isoforms that are translated from Hu-dependent alternative mRNA isoforms. Initially I will focus on studying the functions of the isoforms of the Kif2a gene, which encodes a kinesin motor protein involved in neuronal cytoskeleton dynamics and intracellular cargo transport. I will especially focus on understanding how Kif2a isoforms regulate development of axons and also the transport of cargo to neuronal processes. I believe that my studies will contribute to our knowledge of how neuronal development and physiology is regulated by alternative splicing.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences biological sciences genetics mutation
- medical and health sciences basic medicine physiology
- natural sciences biological sciences genetics RNA
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-RG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
34450 Istanbul
Türkiye
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.