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BRain dEvelopment and Air polluTion ultrafine particles in scHool childrEn

Objectif

Traffic-related air pollution is an important environmental problem that may affect neurodevelopment. Ultrafine particles (UFP) translocate to the brains of experimental animals resulting in local proinflammatory overexpression. As the basic elements for thinking are acquired by developing brains during infancy and childhood, susceptibility may be elevated in early life.

We postulate that traffic-related air pollution (particularly UFPs and metals/hydrocarbons content) impairs neurodevelopment in part via effects on frontal lobe maturation, likely increasing attention-deficit/hyperactivity disorder (ADHD). BREATHE objectives are to develop valid methods to measure children's personal UFP exposure and to develop valid neuroimaging methods to assess correlations between neurobehavior, neurostructural alterations and particle deposition in order to reveal how traffic pollution affects children¿s exposure to key contaminants and brain development, and identify susceptible subgroups.

We have conducted general population birth cohort studies providing preliminary evidence of residential air pollution effects on prenatal growth and mental development.

We aim to demonstrate short and long-term effects on neurodevelopment using innovative epidemiological methods interfaced with environmental chemistry and neuroimaging following 4000 children from 40 schools with contrasting high/low traffic exposure in six linked components involving: repeated psychometric tests, UFP exposure assessment using personal, school and home measurements, gene-environment interactions on inflammation, detoxification pathways and ADHD genome-wide-associated genes, neuroimaging (magnetic resonance imaging/spectroscopy) in ADHD/non-ADHD children, integrative causal modeling using mathematics, and replication in 2900 children with neurodevelopment followed from pregnancy.

We believe the expected results will have worldwide global planning and policy implications.

Appel à propositions

ERC-2010-AdG_20100317
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Régime de financement

ERC-AG - ERC Advanced Grant

Institution d’accueil

FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA
Contribution de l’UE
Aucune donnée
Adresse
C ROSSELLO 132 PLANTA 05
08036 Barcelona
Espagne

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Région
Este Cataluña Barcelona
Type d’activité
Research Organisations
Chercheur principal
Jordi Sunyer Deu (Prof.)
Contact administratif
Joana Porcel (Ms.)
Liens
Coût total
Aucune donnée

Bénéficiaires (4)