Objetivo Understanding the origin and evolution of eukaryotes, their genomes and organelles, are among the most important and exciting challenges facing biology. However, determining ancient gene origins tests methods and data to their limits, and it is unrealistic to expect progress to be easy. A comparative cross-disciplinary approach involving sophisticated phylogenetics allied with mathematical understanding, offers the best hope of obtaining robust hypotheses for gene and genomic origins. It is also necessary to look beyond the narrow focus of a few model organisms, and to thoughtfully embrace a wider selection of eukaryotic diversity. Over the past few years, my lab has studied the genomes and mitochondrial homologues (mitosomes and hydrogenosomes) of parasitic protozoa that represent significant health hazards in both the developed and developing world. These microbial eukaryotes will provide the model systems for investigations which aim to deliver major progress in understanding the importance of lateral gene transfer for eukaryotic genome origins and flux, for understanding how parasites exploit their host cells, and for identifying the essential functions of organelles related to mitochondria, which now appear to be vital components of all eukaryotic cells. Ámbito científico medical and health sciencesmedical biotechnologygenetic engineeringgene therapynatural sciencesbiological sciencesmicrobiologyprotozoologynatural sciencesbiological sciencesgeneticsgenomeseukaryotic genomes Programa(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) ERC-AG-LS8 - ERC Advanced Grant - Evolutionary, population and environmental biology Convocatoria de propuestas ERC-2010-AdG_20100317 Consulte otros proyectos de esta convocatoria Régimen de financiación ERC-AG - ERC Advanced Grant Institución de acogida UNIVERSITY OF NEWCASTLE UPON TYNE Aportación de la UE € 1 998 703,00 Dirección KINGS GATE NE1 7RU Newcastle Upon Tyne Reino Unido Ver en el mapa Región North East (England) Northumberland and Tyne and Wear Tyneside Tipo de actividad Higher or Secondary Education Establishments Investigador principal Thomas Martin Embley (Prof.) Contacto administrativo Fiona Airey (Mrs.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Beneficiarios (1) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo UNIVERSITY OF NEWCASTLE UPON TYNE Reino Unido Aportación de la UE € 1 998 703,00 Dirección KINGS GATE NE1 7RU Newcastle Upon Tyne Ver en el mapa Región North East (England) Northumberland and Tyne and Wear Tyneside Tipo de actividad Higher or Secondary Education Establishments Investigador principal Thomas Martin Embley (Prof.) Contacto administrativo Fiona Airey (Mrs.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
