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Mapping the life histories of T cells

Objective

T cells display many different phenotypes and functions, depending on the nature of previously encountered signals. If we want to understand how these different T cell subsets arise, we need to be able to follow individual T cells and their progeny through time. With the aim to map the life histories of individual T cells we have developed unique technologies that allow us to determine whether different T cell populations arise from common or distinct progenitors.

Within this project we will utilize genetic reporter systems to determine:
1. How T cell recruitment, proliferation and death shape antigen-specific T cell responses
2. At which stage the resulting T cells commit to the effector or the memory T cell lineage
3. The self renewal potential of the tissue-resident memory T cells that remain after infection is cleared

By following T cells and their progeny through time, this project will describe the regulation of cell fate in antigen-specific T cell responses. Furthermore, this project will lead to the creation of novel reporters of cellular history that will be of broad value to analyze cell fate and kinship for a variety of cell types.

Call for proposal

ERC-2010-AdG_20100317
See other projects for this call

Funding Scheme

ERC-AG - ERC Advanced Grant

Host institution

STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
Address
Plesmanlaan 121
1066 CX Amsterdam
Netherlands
Activity type
Research Organisations
EU contribution
€ 2 499 640
Principal investigator
Antonius Nicolaas Maria Schumacher (Prof.)
Administrative Contact
Henri Van Luenen (Dr.)

Beneficiaries (1)

STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
Netherlands
EU contribution
€ 2 499 640
Address
Plesmanlaan 121
1066 CX Amsterdam
Activity type
Research Organisations
Principal investigator
Antonius Nicolaas Maria Schumacher (Prof.)
Administrative Contact
Henri Van Luenen (Dr.)