Objective T cells display many different phenotypes and functions, depending on the nature of previously encountered signals. If we want to understand how these different T cell subsets arise, we need to be able to follow individual T cells and their progeny through time. With the aim to map the life histories of individual T cells we have developed unique technologies that allow us to determine whether different T cell populations arise from common or distinct progenitors.Within this project we will utilize genetic reporter systems to determine:1. How T cell recruitment, proliferation and death shape antigen-specific T cell responses2. At which stage the resulting T cells commit to the effector or the memory T cell lineage3. The self renewal potential of the tissue-resident memory T cells that remain after infection is clearedBy following T cells and their progeny through time, this project will describe the regulation of cell fate in antigen-specific T cell responses. Furthermore, this project will lead to the creation of novel reporters of cellular history that will be of broad value to analyze cell fate and kinship for a variety of cell types. Fields of science humanitieshistory and archaeologyhistory Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) ERC-AG-LS6 - ERC Advanced Grant - Immunity and infection Call for proposal ERC-2010-AdG_20100317 See other projects for this call Funding Scheme ERC-AG - ERC Advanced Grant Coordinator STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS Address Plesmanlaan 121 1066 CX Amsterdam Netherlands See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Research Organisations Administrative Contact Henri Van Luenen (Dr.) Principal investigator Antonius Nicolaas Maria Schumacher (Prof.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Beneficiaries (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS Netherlands EU contribution € 2 499 640,00 Address Plesmanlaan 121 1066 CX Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Research Organisations Administrative Contact Henri Van Luenen (Dr.) Principal investigator Antonius Nicolaas Maria Schumacher (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
