Project description Virtual Physiological Human Show the project objective Hide the project objective In recent years, High-Intensity Focused Ultrasound and Focused Ultrasound (FUS) have become frequent tools for non-invasive benign tumour therapy. Applications in the treatment of fibroadenoma of uterus has become commercial and passed FDA clearance in 2004 and sonication of bone metastasis has obtained a CE mark. Other tumours are under preclinical (prostate, kidney) and clinical (breast, brain and liver) evaluation. However, treating tumours with focused ultrasound is still challenging in terms of reliable therapy planning, monitoring and outcome prediction especially in moving organs with a complex blood supply. It is important to understand that the processes involved in FUS therapy are multi-level ranging from organ morphology, perfusion and motion, down to microscopic and cellular level. The relation within and between these levels is not well understood.FUSIMO will develop, implement and validate a multi-level model for moving abdominal organs for use with FUS and Magnetic resonance-guided focused ultrasound surgery. The overall model will consist of several sub-models, which interact and describe aspects in a hierarchical manner. The integrated model will consist of;- Abdominal organ model to simulate motion and the influence on ultrasound application- Target organ/tumour model to capture organ/tumour physiology, and organ/tumour reaction to therapy- Microscopic tissue model to simulate direct heat ablation, model energy distribution, tissue heating and cooling- Model to evaluate first steps to simulate drug delivery, microbubble distribution and dynamicsThe FUSIMO developments in the field of hardware and software will be combined into an integrated system, which will allow both abdominal FUS application to moving organs, and also other treatment modalities such as radio frequency, laser or cryotherapy or other types of interventions based on particles or fields in radiation therapy. Fields of science engineering and technologyelectrical engineering, electronic engineering, information engineeringinformation engineeringtelecommunicationsradio technologyradio frequencymedical and health sciencesclinical medicinesurgerymedical and health sciencesbasic medicinephysiologynatural sciencesphysical sciencesopticslaser physicsnatural sciencesphysical sciencesacousticsultrasound Programme(s) FP7-ICT - Specific Programme "Cooperation": Information and communication technologies Topic(s) ICT-2009.5.3 - Virtual Physiological Human Call for proposal FP7-ICT-2009-6 See other projects for this call Funding Scheme CP - Collaborative project (generic) Coordinator FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV EU contribution € 881 245,00 Address HANSASTRASSE 27C 80686 Munchen Germany See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Christoph Schulte (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (11) Sort alphabetically Sort by EU Contribution Expand all Collapse all EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Switzerland EU contribution € 373 320,00 Address Raemistrasse 101 8092 Zuerich See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Administrative Contact Gabor Szekely (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data IBSmm Engineering spol. s r. o. Czechia EU contribution € 163 410,00 Address Hybesova 42 60200 Brno See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Michael Mueller (Mr.) Links Contact the organisation Opens in new window Total cost No data MEDIRI GMBH Germany EU contribution € 171 600,00 Address EPPELHEIMER STR 13 69115 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact André Bongers (Dr.) Links Contact the organisation Opens in new window Total cost No data INSIGHTEC LTD Israel EU contribution € 212 100,00 Address Nachum Heth Street 5 39120 TIRAT CARMEL See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Amir Harel (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data GE MEDICAL SYSTEMS ISRAEL LTD Israel EU contribution € 100 000,00 Address 1 NATIV HA OR STREET 3508510 Haifa See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Sara Greenberg (Ms.) Links Contact the organisation Opens in new window Total cost No data UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA Italy EU contribution € 120 200,00 Address Piazzale Aldo Moro 5 00185 Roma See on map Region Centro (IT) Lazio Roma Activity type Higher or Secondary Education Establishments Administrative Contact MARIO BEZZI (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data TECHNISCHE UNIVERSITEIT DELFT Netherlands EU contribution € 178 137,00 Address STEVINWEG 1 2628 CN Delft See on map Region West-Nederland Zuid-Holland Delft en Westland Activity type Higher or Secondary Education Establishments Administrative Contact Jenny Dankelman (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data STIFTELSEN SINTEF Norway EU contribution € 351 060,00 Address STRINDVEIEN 4 7034 Trondheim See on map Region Norge Trøndelag Trøndelag Activity type Research Organisations Administrative Contact Thomas Lango (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Fundatia Medis Romania EU contribution € 122 400,00 Address STRADA NICOLAE BALCESCU 53 105600 CAMPINA See on map Activity type Other Administrative Contact Calin Tiu (Dr.) Links Contact the organisation Opens in new window Total cost No data GEMS PET SYSTEMS AKTIEBOLAG Participation ended Sweden EU contribution € 0,00 Address HUSBYBORG 752 28 Uppsala See on map Region Östra Sverige Östra Mellansverige Uppsala län Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Bengt Nielsen (Dr.) Links Contact the organisation Opens in new window Total cost No data UNIVERSITY OF DUNDEE United Kingdom EU contribution € 798 207,00 Address Nethergate DD1 4HN Dundee See on map Region Scotland Eastern Scotland Angus and Dundee City Activity type Higher or Secondary Education Establishments Administrative Contact Andreas Melzer (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data