Objective
"The olfactory bulb (OB) is one of the few structures in the adult forebrain in which there is a continuous supply of newborn neurons. Neuronal precursors are generated in the subventricular zone (SVZ) and follow an intricate migration path before reaching their final position in the OB.
Familial dysautonomia is a neurodegenerative disorder that result from the impairment of Elongator activity. Elongator is a six unit complex assembled by its scaffold protein Elp1. The host laboratory has recently shown that the catalytic activity of this complex underlies radial migration and branching of cortical projection neurons by promoting the acetylation of α-tubulin.
In the adult brain, the stem/neural progenitor express Elongator subunits and Elp1 level expression increases dramatically after treatment that promotes neurogenesis. The overall goal of the current project is to understand the functions of Elongator in adult brain neurogenesis.
I propose:
- To analyze the expression pattern of Elongator in adult SVZ.
- To dissect the role of Elongator on neuroblasts migration within the rostral migratory stream (rostral migration) and the OB (radial migration).
- To define the role of Elongator on interneuron differentiation in the OB.
- To characterize new cytoplasmic targets of Elongator that promote adult neurogenesis."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
4000 LIEGE
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.