Objective To impact science and society in the way that we feel is possible, synthetic chemistry needs to combine innovation and execution. We are motivated by the idea that novel chemical methodologies are needed to enable the synthesis of novel, previously elusive natural-like scaffolds. Only innovative organic chemistry research can provide the next generation of problem solvers.The goal of the ORGANO-CAS CAT research project proposed here is to exploit the potential of Asymmetric Organocatalysis (which involves only organic elements in the active principle) to find cost-effective, environmentally benign, and sustainable synthetic methods for reproducing the rich structural diversity and complexity of natural molecules. This is in line with the European approach of attaining Sustainable Chemistry (SusChem).Recently, we demonstrated the potential of organocascade catalysis to recreate the intricate structural scaffold and related complex stereochemistry of natural-like compounds with very high fidelity. We want to further innovate around the development of novel organocascade strategies for rapidly converting simple achiral starting materials into complex compounds embodying features of natural molecules. We recognized as a necessary step the identification of novel reactivity concepts to enable the inclusion of unprecedented transformations into elaborate yet experimentally simple organocascade reactions. Specifically we will focus on the development of organocatalytic cascade reaction driven by dynamic kinetic resolution as well as on the inclusion of dienamine activation step within the cascade sequence. In the longer term, organocascade catalysis could become the ideal synthetic starting point for assembling libraries comprising enantiopure molecules, which will increase the probability of success in identifying drug-candidate structures Fields of science natural scienceschemical sciencesorganic chemistrynatural scienceschemical sciencescatalysis Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2010-IIF - Marie Curie Action: "International Incoming Fellowships" Call for proposal FP7-PEOPLE-2010-IIF See other projects for this call Funding Scheme MC-IIF - International Incoming Fellowships (IIF) Coordinator FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA Address Avenida paissos catalans 16 43007 Tarragona Spain See on map Region Este Cataluña Tarragona Activity type Research Organisations Administrative Contact Elias Daura Oller (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data
