Objectif The hippocampus contains a population of stem cells that continually proliferate to produce new neurons. The development of new markers capable of identifying and isolating defined neural stem cell populations are of utmost importance. Prominin-1 has successfully been used as a marker for the isolation of neural stem and progenitor cells from other brain regions including the mouse embryonic forebrain, the adult SVZ and the postnatal cerebellum. However, its potential as a marker of stem cells in the adult hippocampus remains to be confirmed. The first aim of this proposal is to examine the efficacy of Prominin-1 as a potential marker for the isolation and characterisation of hippocampal stem cells.We have recently discovered a dormant or latent population of neural precursors in the adult hippocampus that can be triggered to generate new neurons. Identification and characterisation of the molecules that trigger these latent neural precursors to generate new neurons should lead to the development of radical new therapies to treat neurodegenerative conditions that affect the hippocampus. Two candidate molecules (Prominin-2 and AP2-gamma) have been chosen based on preliminary microarray data and will be examined for their ability stimulate hippocampal neurogenesis. Champ scientifique medical and health sciencesmedical biotechnologycells technologiesstem cells Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) FP7-PEOPLE-2010-IIF - Marie Curie Action: "International Incoming Fellowships" Appel à propositions FP7-PEOPLE-2010-IIF Voir d’autres projets de cet appel Régime de financement MC-IIF - International Incoming Fellowships (IIF) Coordinateur TECHNISCHE UNIVERSITAET DRESDEN Contribution de l’UE € 226 945,00 Adresse HELMHOLTZSTRASSE 10 01069 Dresden Allemagne Voir sur la carte Région Sachsen Dresden Dresden, Kreisfreie Stadt Type d’activité Higher or Secondary Education Establishments Contact administratif Beate Brenner (Mrs.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
