Objective
This project combines computational modeling, electroencephalography (EEG), functional magnetic resonance imaging (fMRI) and neuropharmacology to investigate the modulation of synaptic plasticity by dopamine during learning about both social and reward-based information. The purpose of the project is to evaluate biologically and computationally interpretable models for obtaining quantitative indices of synaptic plasticity during learning using both EEG and fMRI recording methods. To this aim, we apply a learning paradigm that combines both social and reward-based cues to guide behaviour. Following behavioural assessment, this paradigm will be used in pharmacological EEG and fMRI studies of healthy volunteers, employing a double-blind, placebo-controlled between-subject design with dopaminergic agents. Joint EEG and fMRI recordings will be obtained and analysed using state of the art modeling techniques, including novel approaches that embed hierarchical Bayesian learning models into nonlinear dynamic causal models. Specifically, we will test whether the models can quantify drug-induced changes in synaptic plasticity that occur as a function of trial-wise learning variables, such as reward prediction errors. Finally, we will use recent advances in model-based decoding to test whether our models can detect which pharmacological manipulation took place in any given subject. If these models prove to be mechanistically interpretable, this research could pave the way for future development of non-invasive, model-based measures of neurotransmitter regulation of synaptic plasticity in patients with psychiatric disorders.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine psychiatry
- engineering and technology medical engineering diagnostic imaging magnetic resonance imaging
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-IIF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
8006 ZURICH
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.