Objetivo "Understanding of normal and abnormal cardiac excitation and contraction requires the integration of knowledge of myocyte electrophysiology and mechanics with knowledge of dynamic myocardial architecture.The myocardium is structured as stacked 4-6 cells thick (~100 µm) laminae of myocytes, which have a complex architectural arrangement throughout the cardiac wall and have localised regions of abrupt change in orientation.Ventricular structure is not an esoteric consideration of form. Along with other functional and structural properties of the myocardium, fibre and laminar architecture determine i) the spread of myocardial activation and ii) the deformation of the wall in contraction. My hypothesis is that: (i) myocardial systolic thickening is enabled by the sliding of sheets over each other, with the laminar architecture serving to limit shear stress; 2) that sheet sliding will have a role in electromechanical feedback which will influence the initiation, propagation and termination of arrhythmias; 3) that myolaminar sliding will be absent in infarct scars, with consequent large strain in the peri-infarct region and that this will have consequences for structural re-organisation, the propagation of activation and arrhythmogenesis in the surrounding myocardium.These hypotheses will be investigated using ex vivo and in vivo MRI of laminar structure with concurrent electrophysiological (EP) epicardial/endocardial recordings. The study has two phases: (Year 1) preclinical method development in isolated and in situ mouse hearts using high-field strength MRI spectrometers; (Year 2) a translational MRI and EP-mapping in a sheep chronic infarction model. Results will have implications for the fundamental understanding of myocardial architectural dynamics (between systole and diastole) and the role of this in electromechanical feedback, and furthermore, the results will have potential clinical applications." Ámbito científico medical and health sciencesclinical medicinecardiologycardiovascular diseasescardiac arrhythmia Programa(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) FP7-PEOPLE-2010-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Convocatoria de propuestas FP7-PEOPLE-2010-IEF Consulte otros proyectos de esta convocatoria Régimen de financiación MC-IEF - Intra-European Fellowships (IEF) Coordinador CHU HOPITAUX DE BORDEAUX Aportación de la UE € 194 564,00 Dirección RUE DUBERNAT 12 33404 Talence Francia Ver en el mapa Región Nouvelle-Aquitaine Aquitaine Gironde Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Jean-Jacques Jalibert (Mr.) Enlaces Contactar con la organización Opens in new window Coste total Sin datos
