Objectif
Despite the exponentially growing burden that neurodevelopment or neurodegenerative diseases represent in public health, the therapies are mostly inexistent or very limited. Intensive fundamental research on the biological mechanisms of neurological disorders is strongly needed to discover and validate pharmacological treatments. At the same time, there is a pressing need for treatment that would compensate the loss of neurons occurring in a multitude of neurological disorders. Rare clinical trials have promoted the feasibility of stem cell-based therapy in the human brain. However, when significant, the benefits of the treatment were transient, and did not completely stop the progression of the disease. Unfortunately, the physiological causes of success or failure of the grafts remain unclear. It seems thus crucial to develop new human experimental models to resolve those issues.
In this context, the HND proposal is guided by the objective to study the key mechanisms of human neuronal development and more precisely to clarify how human neural progenitors may functionally integrate neural networks. To reach this aim, I will have to achieve the following specific objectives: 1) Developing human experimental neuron-based models, and 2) Developing new strategies to insure the appropriate maturation, integration, function and fate of neural progenitors. The HND project will be performed on neural cell culture obtained from human tissue, by using state-of-the-art genetic reprogramming techniques. The originality of the proposal is to combine several cutting-edge genetic and physiological technologies to approach the topic at cellular and neural network levels in living tissue.
The outcomes of the project will be particularly important to research aiming to identify the biological mechanisms underlying neurological pathologies and validate pharmacological treatments, as well as to restorative cell therapies.
Champ scientifique (EuroSciVoc)
CORDIS classe les projets avec EuroSciVoc, une taxonomie multilingue des domaines scientifiques, grâce à un processus semi-automatique basé sur des techniques TLN. Voir: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classe les projets avec EuroSciVoc, une taxonomie multilingue des domaines scientifiques, grâce à un processus semi-automatique basé sur des techniques TLN. Voir: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- sciences médicales et de la santésciences de la santésanté publique et environnementale
- sciences médicales et de la santémédecine fondamentalepathologie
- sciences médicales et de la santémédecine fondamentaleneurologie
- sciences médicales et de la santébiotechnologie médicaletechnologies cellulaires
- sciences naturellesinformatique et science de l'informationintelligence artificielleintelligence de calcul
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Appel à propositions
FP7-PEOPLE-2010-IOF
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Régime de financement
MC-IOF - International Outgoing Fellowships (IOF)Coordinateur
13284 Marseille
France