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How is phosphoinositide 3-kinase beta regulated by G-Protein Coupled Receptors and by Rab-5?

Publicaciones

Molecular determinants of PI3Kγ-mediated activation downstream of G-protein–coupled receptors (GPCRs)

Autores: Vadas, Oscar; Dbouk, Hashem A.; Shymanets, Aliaksei; Perisic, Olga; Burke, John E.; Abi Saab, Widian F.; Khalil, Bassem D.; Harteneck, Christian; Bresnick, Anne R.; Nürnberg, Bernd; Backer, Jonathan M.; Williams, Roger L.
Publicado en: Proceedings of the National Academy of Sciences PNAS 2013
Identificador permanente: Digital Object Identifier:10.1073/pnas.1304801110; PubMed Central ID:PMC3839701; PubMed ID:24190998

Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage

Autores: Angulo, I.; Vadas, O.; Garcon, F.; Banham-Hall, E.; Plagnol, V.; Leahy, T. R.; Baxendale, H.; Coulter, T.; Curtis, J.; Wu, C.; Blake-Palmer, K.; Perisic, O.; Smyth, D.; Maes, M.; Fiddler, C.; Juss, J.; Cilliers, D.; Markelj, G.; Chandra, A.; Farmer, G.; Kielkowska, A.; Clark, J.; Kracker, S.; Debre, M.; Picard, C.; Pellier, I.; Jabado, N.; Morris, J. A.; Barcenas-Morales, G.; Fischer, A.; Stephens, L.; Hawkins, P.; Barrett, J. C.; Abinun, M.; Clatworthy, M.; Durandy, A.; Doffinger, R.; Chilvers, E. R.; Cant, A. J.; Kumararatne, D.; Okkenhaug, K.; Williams, R. L.; Condliffe, A.; Nejentsev, S.
Identificador permanente: Digital Object Identifier:10.1126/science.1243292; PubMed Central ID:PMC3930011; PubMed ID:24136356

G Protein–Coupled Receptor–Mediated Activation of p110β by Gβγ Is Required for Cellular Transformation and Invasiveness

Autores: G L Waldo; Christine Hsueh; Bassem D. Khalil; Roger L. Williams; Jonathan M. Backer; Hashem A. Dbouk; Olga Perisic; Rachel S. Salamon; Bernd Nürnberg; Mathew O. Barrett; Ronald Taussig; John E. Burke; Alan V. Smrcka; T. Kendall Harden; Christian Harteneck; Chinmay R. Surve; Anne R. Bresnick; Aliaksei Shymanets; Oscar Vadas; Peter R. Shepherd
Identificador permanente: PubMed Central ID:PMC3979326; PubMed ID:23211529; Digital Object Identifier:10.1126/scisignal.2003264