Skip to main content

Binuclear Non-Coupled Copper Enzymes in Neurobiology: An Integrated Computational/Spectroscopic Investigation

Objective

"Every third protein contains metal as cofactor. Cu-enzymes plays crucial rules in key processes in bioenergetics, mitochondrial respiration, neurotransmitter biosynthesis, antioxidation and pigmentation Therefore they are intensive targets for discovering new drugs and the understanding of their structure-functions relationships will provide new insight in translational and biomedical research.
In this Marie Curie International Outgoing Fellowship I will investigate the mechanism of important two bi nuclear cupper enzyme – Peptidylglycine α-Amidating Monooxygenase (PAM) and Dopamine β-Monooxygense (DBM) which catalyze hydroxylation of substrates in crucial importance for neurobiology . The miss functionalities of these enzymes are related with nervous system disorders therefore revealing it mechanism will provide advanced opportunities for design of new drugs. In order to achieve this knowledge we will apply integrated combination of the most advanced spectroscopic techniques and state of the art computational methods."

Call for proposal

FP7-PEOPLE-2010-IOF
See other projects for this call

Coordinator

UNIVERSITY OF NORTHUMBRIA AT NEWCASTLE
Address
Sutherland Building College Street
NE1 8ST Newcastle Upon Tyne
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 258 386,80
Administrative Contact
Gary Black (Prof.)