Obiettivo
"Every third protein contains metal as cofactor. Cu-enzymes plays crucial rules in key processes in bioenergetics, mitochondrial respiration, neurotransmitter biosynthesis, antioxidation and pigmentation Therefore they are intensive targets for discovering new drugs and the understanding of their structure-functions relationships will provide new insight in translational and biomedical research.
In this Marie Curie International Outgoing Fellowship I will investigate the mechanism of important two bi nuclear cupper enzyme – Peptidylglycine α-Amidating Monooxygenase (PAM) and Dopamine β-Monooxygense (DBM) which catalyze hydroxylation of substrates in crucial importance for neurobiology . The miss functionalities of these enzymes are related with nervous system disorders therefore revealing it mechanism will provide advanced opportunities for design of new drugs. In order to achieve this knowledge we will apply integrated combination of the most advanced spectroscopic techniques and state of the art computational methods."
Campo scientifico
Argomento(i)
Invito a presentare proposte
FP7-PEOPLE-2010-IOF
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Meccanismo di finanziamento
MC-IOF - International Outgoing Fellowships (IOF)Coordinatore
NE1 8ST Newcastle Upon Tyne
Regno Unito