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Implant Disposable Antibacterial Coating (I.D.A.C.): a Novel Approach to Implant-Related Infections in Orthopaedics and Trauma Surgery

Objective

With a share of 38%, orthopaedic and traumatology (O&T) are the worldwide leading markets of implanted biomaterials, involving millions of new patients each year at an increasing trend. Infection related to implanted medical devices is directly related to bacterial capability to establish multilayered, highly structured biofilms on artificial surfaces. Bacterial infections due to implanted biomaterials represent the most devastating complication in O&T, involving millions of European citizens. Aim of the present research is to develop, validate and bring to the market a disposable coating of implanted biomaterial (Implant Disposable Antibacterial Coating, I.D.A.C.). The device, based on a novel, proprietary, resorbable hydrogel, would act as a fast resorbable local delivery carrier of antibiofilm and antibacterial compounds. The active drug (antibiofilm and antibiotic agents) will be mixed at the time of the hydrogel application, allowing the correct choice for any given patient, reducing regulatory requirements, improving storage life and versatility. In particular, I.D.A.C. will be tested as a resorbable carrier of drugs (e.g.: N-acetylcisteine and its derivatives, serratia peptidase and other peptides, etc.) already known from our studies for having excellent antibiofilm properties, while others are able to by-pass the intact biofilm barrier and kill the underlying bacteria, when locally administered. The final purpose of the present research is to set a novel approach to early control of biofilm formation,to prevent bacterial colonization of implanted material and to treat established implant-related infections and chronic wounds, without any risk of inducing new drug resistance and alter the environment. The research will be conducted under the aegis of the European Bone and Joint Infection Society and the European Hip Society, through a network of upper standard European research and clinical centers and experienced SMEs from eight Countries around Europe.

Call for proposal

FP7-HEALTH-2011-two-stage
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Coordinator

NOVAGENIT SRL
Address
Viale Trento 115/117
38017 Mezzolombardo
Italy
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 658 138
Administrative Contact
Benedetta Brusati (Ms.)

Participants (11)

KENTRO EREVNAS TECHNOLOGIAS KAI ANAPTYXIS THESSALIAS

Participation ended

Greece
Address
Technologiko Parko A Vipe
38500 Volos
Activity type
Research Organisations
Administrative Contact
Georgia Pahlitzanakis (Ms.)
ADLER ORTHO FRANCE
France
EU contribution
€ 204 174
Address
Route De La Cote D Azur Rue De La Belle Du Canet Arteparc Bat F Le Canet
13590 Meyreuil
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Robert Rodriguez (Mr.)
ADLER ORTHO SRL
Italy
EU contribution
€ 245 675
Address
Via Dell Innovazione 9
20032 Cormano Mi
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Andrea Dasi (Dr.)
BELGAFIX
Belgium
EU contribution
€ 194 874
Address
Rue Longue 286
1620 Drogenbos
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Giovanni Carollo (Mr.)
CF CONSULTING FINANZIAMENTI UNIONE EUROPEA SRL
Italy
EU contribution
€ 123 061
Address
Via Giuseppe Mussi 1
20154 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Carla Finocchiaro (Mrs.)
BONALIVE BIOMATERIALS OY
Finland
EU contribution
€ 148 000
Address
Biolinja 12
20750 Turku
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Fredrik Ollila (Dr.)
ETHNIKO KENTRO EREVNAS KAI TECHNOLOGIKIS ANAPTYXIS
Greece
EU contribution
€ 288 990
Address
Charilaou Thermi Road 6 Km
57001 Thermi Thessaloniki
Activity type
Research Organisations
Administrative Contact
Georgia Pahlitzanakis (Ms.)
ISTITUTO ORTOPEDICO GALEAZZI SPA
Italy
EU contribution
€ 478 126
Address
Via Riccardo Galeazzi 4
20161 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Carlo Luca Romanò (Prof.)
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
EU contribution
€ 263 580
Address
Heidelberglaan 100
3584 CX Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Pieter J.A. De Koning (Dr.)
UNIVERSITATSKLINIKUM HEIDELBERG
Germany
EU contribution
€ 223 647
Address
Im Neuenheimer Feld 672
69120 Heidelberg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Thomas Eisenhauer (Mr.)
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 171 735
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sofie Heroes (Ms.)