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European Consortium for the Early Treatment of Diabetic Retinopathy

Objective

Diabetic retinopathy (DR), the leading cause of blindness among working-age individuals in developed countries has been classically considered to be a microcirculatory disease of the retina. However, there is growing evidence to suggest that retinal neurodegeneration is an early event in the pathogenesis of DR. For this reason, it is reasonable to hypothesize that therapeutic strategies based on neuroprotection will be effective not only in preventing or arresting retinal neurodegeneration but also in preventing the development and progression of the early stages of DR (ie. microaneurysms and/or retinal thickness).
EUROCONDOR (European Consortium for the Early Treatment of Diabetic Retinopathy) is a solid and well balanced consortium (ophthalmologists, endocrinologists, basic researchers) which has been created in order to implement the first clinical trial using eye drops for treatment of the early stages of DR. The participants are top leaders in their field and central readings will be performed by the Coordinating Centre of the European Vision Institute Clinical Research Network (EVICR.Net).
The main objectives of the project are the following:
Primary objective: To assess whether the selected neuroprotective drugs (brimonidine and somatostatin) administered topically are able to prevent or arrest neurodegeneration, as well as the development and progression of the early stages of DR.
Secondary objectives: 1) To determine the prevalence of functional abnormalities related to neurodegeneration in those patients without or with minimal microvascular damage under ophthalmoscopic examination. 2) To compare the effectiveness of the selected drugs. 3) To evaluate the local and systemic adverse effects of the selected drugs. 4) To identify those patients most prone to progressive worsening (characterization of phenotypes and circulating biomarkers). 5) To determine the molecular mechanisms by which the selected drugs exert their beneficial effects.

Call for proposal

FP7-HEALTH-2011-two-stage
See other projects for this call

Coordinator

FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA
Address
Passeig Vall D Hebron 119-129 Edificio De Recerca
08035 Barcelona
Spain
Activity type
Research Organisations
EU contribution
€ 958 679,80
Administrative Contact
Montse Giménez (Mrs.)

Participants (17)

AIBILI ASSOCIACAO PARA INVESTIGACAO BIOMEDICA E INNOVACAO EM LUZ E IMAGEM
Portugal
EU contribution
€ 958 425,35
Address
Azinhaga De Santa Comba, Celas
3000 548 Coimbra
Activity type
Research Organisations
Administrative Contact
Cecilia Martinho (Ms.)
SYDDANSK UNIVERSITET
Denmark
EU contribution
€ 317 239,38
Address
Campusvej 55
5230 Odense M
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Arne Bækdal Hansen (Mr.)
UNIVERSITAET ULM
Germany
EU contribution
€ 255 601,83
Address
Helmholtzstrasse 16
89081 Ulm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Frank Gleixner (Mr.)
UNIVERSITA VITA-SALUTE SAN RAFFAELE
Italy
EU contribution
€ 287 238,63
Address
Via Olgettina 58
20132 Milano
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maria Rosa Pedrazzi (Dr.)
UNIVERSITA DEGLI STUDI DI PADOVA
Italy
EU contribution
€ 270 601,83
Address
Via 8 Febbraio 2
35122 Padova
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Domenico D‘avella (Prof.)
GLOUCESTERSHIRE HOSPITALS NHS FOUNDATION TRUST
United Kingdom
EU contribution
€ 325 601,84
Address
College Lawn 1
GL53 7AG Cheltenham
Activity type
Research Organisations
Administrative Contact
Emma Jackson (Ms.)
INSTITUT CATALA DE LA SALUT
Spain
EU contribution
€ 330 601,83
Address
Gran Via De Les Corts Catalanes 587
08007 Barcelona
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Lluis Masso (Mr.)
MOORFIELDS EYE HOSPITAL NHS FOUNDATION TRUST
United Kingdom
EU contribution
€ 195 601,83
Address
City Road 162
EC1V 2PD London
Activity type
Research Organisations
Administrative Contact
Sue Lydeard (Ms.)
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
France
EU contribution
€ 180 601,83
Address
3 Avenue Victoria
75000 Paris
Activity type
Research Organisations
Administrative Contact
Christophe Misse (Mr.)
THE UNIVERSITY OF LIVERPOOL
United Kingdom
EU contribution
€ 227 238,63
Address
Brownlow Hill 765 Foundation Building
L69 7ZX Liverpool
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Pam Neagle (Ms.)
ASTON UNIVERSITY
United Kingdom
EU contribution
€ 280 601,83
Address
Aston Triangle
B4 7ET Birmingham
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gareth A Evans (Mr.)
UNIVERSITA DEGLI STUDI DI TORINO
Italy
EU contribution
€ 156 400
Address
Via Giuseppe Verdi 8
10124 Torino
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rosa Maria Pilato (Ms.)
FUNDACION DE LA COMUNIDAD VALENCIANA CENTRO DE INVESTIGACION PRINCIPEFELIPE
Spain
EU contribution
€ 76 123,85
Address
Calle Eduardo Primo Yufera 3
46012 Valencia
Activity type
Research Organisations
Administrative Contact
Ana Alvarez Llanas (Ms.)
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 121 721,65
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
Administrative Contact
Eusebio Jiménez Arroyo (Mr.)
FEDERATION INTERNATIONALE DU DIABETE REGION EUROPE AISBL
Belgium
EU contribution
€ 156 000
Address
Avenue Du Bourgemestre Etienne Demunter 5B
1090 Brussels
Activity type
Other
Administrative Contact
Sophie Peresson (Ms.)
BCN PEPTIDES SA
Spain
EU contribution
€ 811 892,19
Address
Carretera Comarcal C-244 Km 22 Poligon Industrial Els Fogars Sector Ii
08777 Santa Quinti De Mediona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Alex Claramunt Llopis (Mr.)
CONSORCIO DE APOYO A LA INVESTIGACION BIOMEDICA EN RED

Participation ended

Spain
EU contribution
€ 88 589,70
Address
Calle Sinesio Delgado 6
28029 Madrid
Activity type
Research Organisations
Administrative Contact
Almudena Moreno (Ms.)