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European Consortium for the Early Treatment of Diabetic Retinopathy

Objetivo

Diabetic retinopathy (DR), the leading cause of blindness among working-age individuals in developed countries has been classically considered to be a microcirculatory disease of the retina. However, there is growing evidence to suggest that retinal neurodegeneration is an early event in the pathogenesis of DR. For this reason, it is reasonable to hypothesize that therapeutic strategies based on neuroprotection will be effective not only in preventing or arresting retinal neurodegeneration but also in preventing the development and progression of the early stages of DR (ie. microaneurysms and/or retinal thickness).
EUROCONDOR (European Consortium for the Early Treatment of Diabetic Retinopathy) is a solid and well balanced consortium (ophthalmologists, endocrinologists, basic researchers) which has been created in order to implement the first clinical trial using eye drops for treatment of the early stages of DR. The participants are top leaders in their field and central readings will be performed by the Coordinating Centre of the European Vision Institute Clinical Research Network (EVICR.Net).
The main objectives of the project are the following:
Primary objective: To assess whether the selected neuroprotective drugs (brimonidine and somatostatin) administered topically are able to prevent or arrest neurodegeneration, as well as the development and progression of the early stages of DR.
Secondary objectives: 1) To determine the prevalence of functional abnormalities related to neurodegeneration in those patients without or with minimal microvascular damage under ophthalmoscopic examination. 2) To compare the effectiveness of the selected drugs. 3) To evaluate the local and systemic adverse effects of the selected drugs. 4) To identify those patients most prone to progressive worsening (characterization of phenotypes and circulating biomarkers). 5) To determine the molecular mechanisms by which the selected drugs exert their beneficial effects.

Convocatoria de propuestas

FP7-HEALTH-2011-two-stage
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Coordinador

FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA
Dirección
Passeig Vall D Hebron 119-129 Edificio De Recerca
08035 Barcelona
España
Tipo de actividad
Research Organisations
Aportación de la UE
€ 958 679,80
Contacto administrativo
Montse Giménez (Mrs.)

Participantes (17)

AIBILI ASSOCIACAO PARA INVESTIGACAO BIOMEDICA E INNOVACAO EM LUZ E IMAGEM
Portugal
Aportación de la UE
€ 958 425,35
Dirección
Azinhaga De Santa Comba, Celas
3000 548 Coimbra
Tipo de actividad
Research Organisations
Contacto administrativo
Cecilia Martinho (Ms.)
SYDDANSK UNIVERSITET
Dinamarca
Aportación de la UE
€ 317 239,38
Dirección
Campusvej 55
5230 Odense M
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Arne Bækdal Hansen (Mr.)
UNIVERSITAET ULM
Alemania
Aportación de la UE
€ 255 601,83
Dirección
Helmholtzstrasse 16
89081 Ulm
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Frank Gleixner (Mr.)
UNIVERSITA VITA-SALUTE SAN RAFFAELE
Italia
Aportación de la UE
€ 287 238,63
Dirección
Via Olgettina 58
20132 Milano
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Maria Rosa Pedrazzi (Dr.)
UNIVERSITA DEGLI STUDI DI PADOVA
Italia
Aportación de la UE
€ 270 601,83
Dirección
Via 8 Febbraio 2
35122 Padova
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Domenico D‘avella (Prof.)
GLOUCESTERSHIRE HOSPITALS NHS FOUNDATION TRUST
United Kingdom
Aportación de la UE
€ 325 601,84
Dirección
Trust Headquarters Alexandra House Cheltenham General Hospital Sandford Road
GL53 7AN Cheltenham
Tipo de actividad
Research Organisations
Contacto administrativo
Emma Jackson (Ms.)
INSTITUT CATALA DE LA SALUT
España
Aportación de la UE
€ 330 601,83
Dirección
Gran Via De Les Corts Catalanes 587
08007 Barcelona
Tipo de actividad
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Contacto administrativo
Lluis Masso (Mr.)
MOORFIELDS EYE HOSPITAL NHS FOUNDATION TRUST
United Kingdom
Aportación de la UE
€ 195 601,83
Dirección
City Road 162
EC1V 2PD London
Tipo de actividad
Research Organisations
Contacto administrativo
Sue Lydeard (Ms.)
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
Francia
Aportación de la UE
€ 180 601,83
Dirección
3 Avenue Victoria
75000 Paris
Tipo de actividad
Research Organisations
Contacto administrativo
Christophe Misse (Mr.)
THE UNIVERSITY OF LIVERPOOL
United Kingdom
Aportación de la UE
€ 227 238,63
Dirección
Brownlow Hill 765 Foundation Building
L69 7ZX Liverpool
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Pam Neagle (Ms.)
ASTON UNIVERSITY
United Kingdom
Aportación de la UE
€ 280 601,83
Dirección
Aston Triangle
B4 7ET Birmingham
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Gareth A Evans (Mr.)
UNIVERSITA DEGLI STUDI DI TORINO
Italia
Aportación de la UE
€ 156 400
Dirección
Via Giuseppe Verdi 8
10124 Torino
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Rosa Maria Pilato (Ms.)
FUNDACION DE LA COMUNIDAD VALENCIANA CENTRO DE INVESTIGACION PRINCIPEFELIPE
España
Aportación de la UE
€ 76 123,85
Dirección
Calle Eduardo Primo Yufera 3
46012 Valencia
Tipo de actividad
Research Organisations
Contacto administrativo
Ana Alvarez Llanas (Ms.)
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
España
Aportación de la UE
€ 121 721,65
Dirección
Calle Serrano 117
28006 Madrid
Tipo de actividad
Research Organisations
Contacto administrativo
Eusebio Jiménez Arroyo (Mr.)
FEDERATION INTERNATIONALE DU DIABETE REGION EUROPE AISBL
Bélgica
Aportación de la UE
€ 156 000
Dirección
Avenue Du Bourgemestre Etienne Demunter 5B
1090 Brussels
Tipo de actividad
Other
Contacto administrativo
Sophie Peresson (Ms.)
BCN PEPTIDES SA
España
Aportación de la UE
€ 811 892,19
Dirección
Carretera Comarcal C-244 Km 22 Poligon Industrial Els Fogars Sector Ii
08777 Santa Quinti De Mediona
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Alex Claramunt Llopis (Mr.)
CONSORCIO DE APOYO A LA INVESTIGACION BIOMEDICA EN RED

La participación finalizó

España
Aportación de la UE
€ 88 589,70
Dirección
Calle Sinesio Delgado 6
28029 Madrid
Tipo de actividad
Research Organisations
Contacto administrativo
Almudena Moreno (Ms.)