Objective
There exist very few techniques for studying a group of cells containing
a large number compared to a single cell but small compared to a whole
tissue. This implies that statistics are exceedingly difficult to obtain
from measurements of individual cells. Microfluidics provides a way to
amend this by allowing ways to observe individual cells and automate
such measurements. The aim in this project is to develop a cell
manipulation platforms based on microfluidics techniques developed in
our lab, while answering relevant biological questions.
The first question concerns Sickle Cell Anemia, a genetic disease for
which no treatment exists. We will study the polymerization of
hemoglobin within red blood cells, as they are submitted to cycles of
oxygenation and deoxygenation. Quantitative measurements of the response
of the cells to oxygen variations will allow physiological conditions to
be simulated, including in the presence of therapeutic candidates or
other biological agents.
The second question concerns the motility of adherent cells in a
three-dimensional environment. This question will be to understand the
migration of cells in a 3D gradient of chemo-attractant, as well as
gradients of rigidity of the environment. This part will require the
development of new technological tools which can later be applied to a
wide range of biological problems. The long term aim is to replace the
current tools of biological labs with miniaturized and integrated lab on
a chip devices.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences classical mechanics fluid mechanics microfluidics
- medical and health sciences clinical medicine hematology
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2011-StG_20101014
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.