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Biodegradable Magnetic Stent for Coronary Artery Luminal Regeneration

Objective

By 2010 1.5 million stents per year will be deployed in Europe. Although outcome for patients has improved, stents still fail because of the occurrence of restenosis and thrombosis at the site of implantation. While drug eluting stents have helped to reduce the problem of restenosis, neointimal proliferation causing restenosis can still occur. Additional concerns exist regarding drug eluting stents as there appears to be a small but real increase in late and very late stent thrombosis, particularly after discontinuation of antiplatelet therapy.
The novel concept we propose is use of a biodegradable magnetised stent (BMS) to deliver a novel biological therapy offering regenerative medicine solutions to the coronary artery vessel wall. Specifically we will develop the stent technology as a platform to attract autologous progenitor cells tagged in vitro with iron nanoparticles. Once deployed, the cells will be attracted to the already implanted BMS and proliferate to form a new endothelium. We will also use over-expression of the NRP1 gene in the artery wall where it will dimerise with NRP1 receptors on the deployed cells. The NRP1 gene will be transfected by adenovirus delivered from the wall of the BMS. Over time the BMS will undergo a predictable degradation to leave a wholly biological artery through regeneration of native tissues.
Currently, about 12,000 European Citizens a year suffer from late in-stent thrombosis and 120,000 from restenosis. With the knowledge and technologies developed through the BIOMAGSCAR project we aim to halve this number of patients and save 66,000 people from unnecessary suffering, saving the European healthcare system €275 million p.a. in direct costs, only 10% of the total associated costs.
Our consortium includes a vascular disease therapy company, a stent research and manufacturing company, four universities and a specialist in innovative technology investment, all of whom believe our technology will dramatically change this field.

Call for proposal

FP7-HEALTH-2011-two-stage
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

UCL Elizabeth Garrett Anderson Institute for Women’s Health
Address
Gower Street
WC1E 6BT London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 772 038,20
Administrative Contact
Kimberly Cornfield (Ms.)

Participants (7)

QUALIMED INNOVATIVE MEDIZINPRODUKTE GMBH
Germany
EU contribution
€ 1 031 502
Address
Boschstrasse 16
21423 Winsen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Georg Göllmann (Mr.)
FINVECTOR VISION THERAPIES LIMITED

Participation ended

United Kingdom
EU contribution
€ 83 801
Address
Whitfield Street 44-46 Floor 4
W1T2RJ London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Russell Banks (Mr.)
ITA-SUOMEN YLIOPISTO
Finland
EU contribution
€ 1 035 981
Address
Yliopistonranta 1 E
70211 Kuopio
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tiina Reinikainen (Ms.)
MAGNUS INVENTION MANAGEMENT LTD
United Kingdom
EU contribution
€ 601 353
Address
Glasslyn Road 39
N8 8RJ London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Mads Asprem (Mr.)
EURAM LIMITED

Participation ended

United Kingdom
EU contribution
€ 319 687,80
Address
Lucy Tower Street Tower House
LN1 1XW Lincoln
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Andrew Banasik (Mr.)
QUEEN MARY UNIVERSITY OF LONDON
United Kingdom
EU contribution
€ 478 005
Address
327 Mile End Road
E1 4NS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tanya Szendeffy (Ms.)
YALE UNIVERSITY
United States
EU contribution
€ 977 110
Address
Whitney Avenue 155 Room 214
06520 8337 New Haven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jeffrey Mcguinness (Mr.)