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Development of antibiofilm coatings for implants

Objective

The aim of the SME-driven COATIM consortium is to tackle the increasing problem of infections due to biofilms, groups of microorganisms that stick together on different surfaces within the human body and escape conventional antibiotic treatment. Biofilms are typically found on medical devices like implants. The most recent generation of implants with open porosity enable fast osseointegration, but also present an increased risk of microbial biofilm-associated infection. Biofilm-associated infections are responsible for 15-25% of implant failure, and necessitate burdensome and costly revision surgery. The latter is estimated to represent a supplementary medical cost of €800m/year in Europe without taking into account the pain and distress of the patients, indicating that any significant reduction of this type of implant failure is highly recommended. Until now, biocidal implant coatings have been developed that are based on either the release of silver ions, which are toxic upon accumulation, or on conventional antibiotics that have poor activity against microorganisms in biofilms. Therefore, COATIM aims to develop the next generation of implant coatings containing novel potent proprietary antibiofilm molecules (ABMs) with inhibitory activity against microbial biofilms. In COATIM, these ABMs are grafted or deposited on small titanium implant substrates, as a model for dental and orthopaedic implants. Next, the ABM-coated implants are evaluated for in vitro and in vivo activity in resisting microbial infection without compromising osseointegration. Finally, the ABM-coating is applied on complex orthopaedic and dental implants, allowing the exploitation of the results by industry. In parallel, the antibiofilm mode of action of the ABMs is unraveled. COATIM contributes to a dynamic and competitive knowledge-based economy, sustainable development, and serves the needs of the SME-intensive medical technology products market in Europe.

Call for proposal

FP7-HEALTH-2011-two-stage
See other projects for this call

Coordinator

KATHOLIEKE UNIVERSITEIT LEUVEN
Address
Oude Markt 13
3000 Leuven
Belgium
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 314 442,94
Administrative Contact
Myriam Witvrouw (Dr.)

Participants (10)

VIB VZW
Belgium
EU contribution
€ 249 995
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Activity type
Research Organisations
Administrative Contact
Rik Audenaert (Mr.)
UNIVERSITY OF LEEDS
United Kingdom
EU contribution
€ 250 000
Address
Woodhouse Lane
LS2 9JT Leeds
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Martin Hamilton (Mr.)
SIK - INSTITUTET FOER LIVSMEDEL OCH BIOTEKNIK AB
Sweden
EU contribution
€ 150 000
Address
Box 5401
40229 Goeteborg
Activity type
Research Organisations
Administrative Contact
Maud Langton (Prof.)
UNIVERZA V LJUBLJANI
Slovenia
EU contribution
€ 55 000
Address
Kongresni Trg 12
1000 Ljubljana
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gregor Majdic (Prof.)
HEMOTEQ AG
Germany
EU contribution
€ 274 774
Address
Adenauerstrasse 15
52146 Wurselen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Thomas Löwen (Mr.)
ALHENIA AG
Switzerland
EU contribution
€ 339 750
Address
Täfernstrasse 39
5405 Daettwil
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jasminka Kovac (Ms.)
EDUCELL PODJETJE ZA CELICNO BIOLOGI JO DOO
Slovenia
EU contribution
€ 300 614
Address
Prevale 9
1236 Trzin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Anja Planina (Ms.)
BIOTECH INTERNATIONAL

Participation ended

France
EU contribution
€ 58 709,25
Address
Allees De Craponne 305
13300 Salon De Provence
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Frederic Impellizzeri (Mr.)
BIOFILM CONTROL SAS
France
EU contribution
€ 6 650,80
Address
Biopole Clermont Limagne
63360 Saint-beauzire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Thierry Bernardi (Dr.)
RISE RESEARCH INSTITUTES OF SWEDEN AB
Sweden
Address
Brinellgatan 4
501 15 Boras
Activity type
Research Organisations
Administrative Contact
Karin Ottosson (Mrs.)