Objective The aim of the SME-driven COATIM consortium is to tackle the increasing problem of infections due to biofilms, groups of microorganisms that stick together on different surfaces within the human body and escape conventional antibiotic treatment. Biofilms are typically found on medical devices like implants. The most recent generation of implants with open porosity enable fast osseointegration, but also present an increased risk of microbial biofilm-associated infection. Biofilm-associated infections are responsible for 15-25% of implant failure, and necessitate burdensome and costly revision surgery. The latter is estimated to represent a supplementary medical cost of €800m/year in Europe without taking into account the pain and distress of the patients, indicating that any significant reduction of this type of implant failure is highly recommended. Until now, biocidal implant coatings have been developed that are based on either the release of silver ions, which are toxic upon accumulation, or on conventional antibiotics that have poor activity against microorganisms in biofilms. Therefore, COATIM aims to develop the next generation of implant coatings containing novel potent proprietary antibiofilm molecules (ABMs) with inhibitory activity against microbial biofilms. In COATIM, these ABMs are grafted or deposited on small titanium implant substrates, as a model for dental and orthopaedic implants. Next, the ABM-coated implants are evaluated for in vitro and in vivo activity in resisting microbial infection without compromising osseointegration. Finally, the ABM-coating is applied on complex orthopaedic and dental implants, allowing the exploitation of the results by industry. In parallel, the antibiofilm mode of action of the ABMs is unraveled. COATIM contributes to a dynamic and competitive knowledge-based economy, sustainable development, and serves the needs of the SME-intensive medical technology products market in Europe. Fields of science engineering and technologymaterials engineeringcoating and filmsmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibioticsmedical and health sciencesclinical medicineorthopaedicsmedical and health sciencesmedical biotechnologyimplantsnatural sciencesbiological sciencesmicrobiology Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2011.2.3.1-5 - Development of tools to control microbial biofilms with relevance to clinical drug resistance Call for proposal FP7-HEALTH-2011-two-stage See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator KATHOLIEKE UNIVERSITEIT LEUVEN Address Oude markt 13 3000 Leuven Belgium See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Higher or Secondary Education Establishments Administrative Contact Myriam Witvrouw (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (10) Sort alphabetically Sort by EU Contribution Expand all Collapse all VIB VZW Belgium EU contribution € 249 995,00 Address Rijvisschestraat 120 9052 Zwijnaarde - gent See on map Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Research Organisations Administrative Contact Rik Audenaert (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITY OF LEEDS United Kingdom EU contribution € 250 000,00 Address Woodhouse lane LS2 9JT Leeds See on map Region Yorkshire and the Humber West Yorkshire Leeds Activity type Higher or Secondary Education Establishments Administrative Contact Martin Hamilton (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data SIK - INSTITUTET FOER LIVSMEDEL OCH BIOTEKNIK AB Sweden EU contribution € 150 000,00 Address Box 5401 402 29 Goeteborg See on map Activity type Research Organisations Administrative Contact Maud Langton (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERZA V LJUBLJANI Slovenia EU contribution € 55 000,00 Address Kongresni trg 12 1000 Ljubljana See on map Region Slovenija Zahodna Slovenija Osrednjeslovenska Activity type Higher or Secondary Education Establishments Administrative Contact Gregor Majdic (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data HEMOTEQ AG Germany EU contribution € 274 774,00 Address Adenauerstrasse 15 52146 Wurselen See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Thomas Löwen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data ALHENIA AG Switzerland EU contribution € 339 750,00 Address Täfernstrasse 39 5405 Daettwil See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jasminka Kovac (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data EDUCELL PODJETJE ZA CELICNO BIOLOGI JO DOO Slovenia EU contribution € 300 614,00 Address Prevale 9 1236 Trzin See on map Region Slovenija Zahodna Slovenija Osrednjeslovenska Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Anja Planina (Ms.) Links Contact the organisation Opens in new window Other funding No data BIOTECH INTERNATIONAL Participation ended France EU contribution € 58 709,25 Address Allees de craponne 305 13300 Salon de provence See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Frederic Impellizzeri (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data BIOFILM CONTROL SAS France EU contribution € 6 650,80 Address Biopole clermont limagne 63360 Saint-beauzire See on map Region Auvergne-Rhône-Alpes Auvergne Puy-de-Dôme Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Thierry Bernardi (Dr.) Links Contact the organisation Opens in new window Other funding No data RISE RESEARCH INSTITUTES OF SWEDEN AB Sweden EU contribution € 0,00 Address Brinellgatan 4 501 15 Boras See on map Region Södra Sverige Västsverige Västra Götalands län Activity type Research Organisations Administrative Contact Karin Ottosson (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
