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Development of antibiofilm coatings for implants

Obiettivo

The aim of the SME-driven COATIM consortium is to tackle the increasing problem of infections due to biofilms, groups of microorganisms that stick together on different surfaces within the human body and escape conventional antibiotic treatment. Biofilms are typically found on medical devices like implants. The most recent generation of implants with open porosity enable fast osseointegration, but also present an increased risk of microbial biofilm-associated infection. Biofilm-associated infections are responsible for 15-25% of implant failure, and necessitate burdensome and costly revision surgery. The latter is estimated to represent a supplementary medical cost of €800m/year in Europe without taking into account the pain and distress of the patients, indicating that any significant reduction of this type of implant failure is highly recommended. Until now, biocidal implant coatings have been developed that are based on either the release of silver ions, which are toxic upon accumulation, or on conventional antibiotics that have poor activity against microorganisms in biofilms. Therefore, COATIM aims to develop the next generation of implant coatings containing novel potent proprietary antibiofilm molecules (ABMs) with inhibitory activity against microbial biofilms. In COATIM, these ABMs are grafted or deposited on small titanium implant substrates, as a model for dental and orthopaedic implants. Next, the ABM-coated implants are evaluated for in vitro and in vivo activity in resisting microbial infection without compromising osseointegration. Finally, the ABM-coating is applied on complex orthopaedic and dental implants, allowing the exploitation of the results by industry. In parallel, the antibiofilm mode of action of the ABMs is unraveled. COATIM contributes to a dynamic and competitive knowledge-based economy, sustainable development, and serves the needs of the SME-intensive medical technology products market in Europe.

Invito a presentare proposte

FP7-HEALTH-2011-two-stage
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Coordinatore

KATHOLIEKE UNIVERSITEIT LEUVEN
Indirizzo
Oude Markt 13
3000 Leuven
Belgio

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Myriam Witvrouw (Dr.)
Contributo UE
€ 1 314 442,94

Partecipanti (10)

VIB VZW
Belgio
Contributo UE
€ 249 995
Indirizzo
Rijvisschestraat 120
9052 Zwijnaarde - Gent

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Tipo di attività
Research Organisations
Contatto amministrativo
Rik Audenaert (Mr.)
UNIVERSITY OF LEEDS
United Kingdom
Contributo UE
€ 250 000
Indirizzo
Woodhouse Lane
LS2 9JT Leeds

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Martin Hamilton (Mr.)
SIK - INSTITUTET FOER LIVSMEDEL OCH BIOTEKNIK AB
Svezia
Contributo UE
€ 150 000
Indirizzo
Box 5401
402 29 Goeteborg

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Tipo di attività
Research Organisations
Contatto amministrativo
Maud Langton (Prof.)
UNIVERZA V LJUBLJANI
Slovenia
Contributo UE
€ 55 000
Indirizzo
Kongresni Trg 12
1000 Ljubljana

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Gregor Majdic (Prof.)
HEMOTEQ AG
Germania
Contributo UE
€ 274 774
Indirizzo
Adenauerstrasse 15
52146 Wurselen

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Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Thomas Löwen (Mr.)
ALHENIA AG
Svizzera
Contributo UE
€ 339 750
Indirizzo
Täfernstrasse 39
5405 Daettwil

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Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Jasminka Kovac (Ms.)
EDUCELL PODJETJE ZA CELICNO BIOLOGI JO DOO
Slovenia
Contributo UE
€ 300 614
Indirizzo
Prevale 9
1236 Trzin

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Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Anja Planina (Ms.)
BIOTECH INTERNATIONAL

Partecipazione conclusa

Francia
Contributo UE
€ 58 709,25
Indirizzo
Allees De Craponne 305
13300 Salon De Provence
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Frederic Impellizzeri (Mr.)
BIOFILM CONTROL SAS
Francia
Contributo UE
€ 6 650,80
Indirizzo
Biopole Clermont Limagne
63360 Saint-beauzire

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Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Thierry Bernardi (Dr.)
RISE RESEARCH INSTITUTES OF SWEDEN AB
Svezia
Indirizzo
Brinellgatan 4
501 15 Boras

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Tipo di attività
Research Organisations
Contatto amministrativo
Karin Ottosson (Mrs.)