Objective Glycosylation is a post-translational modification that enriches protein complexity and function. Dysregulation of glycosylation is associated with a wide range of diseases, including cancer, diabetes, as well as congenital, cardiovascular, immunological and infectious disorders. A number of studies identified potentially important glycan disease biomarkers. With regard to biotechnology, proper glycosylation of biologicals is important, as deviations in glycosylation are known to be associated with adverse drug reactions and reduced therapeutic efficacy. However, glycomics is significantly lagging behind genomics and proteomics, mainly due to the absence of high-throughput analytical methods which can reliably quantify a multitude of glycan structures in complex biological samples.We are confident that by coordinated efforts of leading European scientists in glycan analysis using HPLC, MS and CGE-LIF technologies this project will make a decisive step forward by developing real high-throughput tools for glycosylation analysis. By teaming up with leading European researchers in the field of genome wide association studies this project will perform validation of all methods on extremely well characterized set of samples resulting from the FP6 EuroSpan project. The addition of the newly generated glycome data to the pre-existing information about these individuals will enable development of methods for the systems biology approach analysis of the glycome which will integrate glycomic, genomic and environmental data about thousands of individuals. The same methods will also be adapted for quality control and monitoring in the production of biopharmaceuticals.Strong participation of SMEs in the project and close contacts with large industrial partners will ensure that research accomplishments achieved by collaboration between academic and industrial scientists are swiftly transformed into innovative products and services for the benefit of European industry. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsmedical and health sciencesclinical medicineendocrinologydiabetesnatural sciencesbiological sciencesbiochemistrybiomoleculescarbohydratesmedical and health sciencesclinical medicineoncologymedical and health sciencesbasic medicinepharmacology and pharmacyadverse drug reactions Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2011.1.1-1 - SME-targeted research for developing tools and technologies for high-throughput research Call for proposal FP7-HEALTH-2011-two-stage See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator ACADEMISCH ZIEKENHUIS LEIDEN Address Albinusdreef 2 2333 ZA Leiden Netherlands See on map Region West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Activity type Higher or Secondary Education Establishments Administrative Contact Manfred Wuhrer (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (8) Sort alphabetically Sort by EU Contribution Expand all Collapse all THE UNIVERSITY OF EDINBURGH United Kingdom EU contribution € 468 680,00 Address Old college, south bridge EH8 9YL Edinburgh See on map Region Scotland Eastern Scotland Edinburgh Activity type Higher or Secondary Education Establishments Administrative Contact Gemma Scott-Wood (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Germany EU contribution € 328 100,00 Address Hofgartenstrasse 8 80539 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Erdmann Rapp (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data NATIONAL INSTITUTE FOR BIOPROCESSING RESEARCH AND TRAINING LIMITED Ireland EU contribution € 589 120,00 Address Fosters avenue mount merrion 4 Blackrock dublin See on map Region Ireland Eastern and Midland Dublin Activity type Research Organisations Administrative Contact Pauline Mary Rudd (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data GENOS DOO ZA VJESTACENJE I ANALIZU Croatia EU contribution € 988 579,60 Address Drniska ulica 9 31000 Osijek See on map Region Hrvatska Panonska Hrvatska Osječko-baranjska županija Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Gordan Lauc (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data SARTORIUS BIA SEPARATIONS, SEPARACIJSKE TEHNOLOGIJE, D.O.O. Slovenia EU contribution € 484 400,00 Address Mirce 21 5270 Ajdovscina See on map Region Slovenija Zahodna Slovenija Goriška Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jana Vidič (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data LUDGER LIMITED United Kingdom EU contribution € 1 011 232,00 Address Culham science centre - building e1 OX14 3EB Abingdon See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Daryl Fernandes (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data MP BIOMEDICALS SARL France EU contribution € 115 800,00 Address Rue jean geiler de kaysersberg 67400 Illkirch-graffenstaden See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Miodrag Micic (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data GLYXERA GMBH Germany EU contribution € 374 100,00 Address Brenneckestrasse 20 zenit 39120 Magdeburg See on map Region Sachsen-Anhalt Sachsen-Anhalt Magdeburg, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Thomas Hermsdorfer (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
