Objective Multiple Myeloma (MM) is an incurable disease with rapidly growing prevalence and poor prognosis. Consequently, it is the goal of the OPTATIO consortium to seek out novel strategies for the development of novel diagnostic and therapeutic options. The MM pathogenesis involves not only genetic changes within the tumour cells but also the emergence of supportive conditions by the bone marrow microenvironment (BMM). To target the essential components of this support system, it is the goal of the project to establish preclinical in vitro and in vivo models of MM that include functionally relevant elements of the BMM. The OPTATIO consortium will therefore analyse clinical data to correlate the presence of particular MM-BMM interactions with the pathogenesis of MM, with its intrinsic therapy resistance as well as with disease relapse due to the development of acquired drug resistance. These correlative data will be validated using autologous MM-BMM co-culture assays and reverse translated into in vitro screening and in vivo models, which will be subsequently used to develop lead compounds that target myeloma cells within their microenvironment.The clinical expertise of several oncological divisions, the research experience of academic laboratories and the pharmaceutical know-how of small and medium sized enterprises as well as biotech industry joined their efforts within the OPTATIO consortium to drive this important development and to ensure translation towards clinical trials.Expected impacts of the project include establishment of better diagnostics, new drug screening approaches for MM and novel personalised therapies based on individual ex vivo phenotyping leading to reduced patient mortality. Since envisaged drug screening methods are applicable to other areas of research and development, the project results will open new markets for industry partners in the fields of drug discovery and pharmaceutical development of products and services for personalized medicine. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverysocial sciencessociologydemographymortalitymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsmedical and health sciencesbasic medicinepharmacology and pharmacydrug resistancemedical and health scienceshealth sciencespersonalized medicine Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2011.2.4.1-2 - Translational research on cancers with poor prognosis Call for proposal FP7-HEALTH-2011-two-stage See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator MEDIZINISCHE UNIVERSITAT INNSBRUCK Address Christoph probst platz 1 6020 Innsbruck Austria See on map Region Westösterreich Tirol Innsbruck Activity type Higher or Secondary Education Establishments Administrative Contact Wolfgang Willenbacher (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (11) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT Germany EU contribution € 287 956,80 Address Josef-schneider-strasse 2 97080 Wurzburg See on map Region Bayern Unterfranken Würzburg, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Melanie Bauer (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data Masarykova univerzita Czechia EU contribution € 279 600,00 Address Zerotinovo namesti 9 601 77 Brno See on map Region Česko Jihovýchod Jihomoravský kraj Activity type Higher or Secondary Education Establishments Administrative Contact Sabina Sevcikova (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITA DEGLI STUDI DI BARI ALDO MORO Italy EU contribution € 262 800,00 Address Piazza umberto i 1 70121 Bari See on map Region Sud Puglia Bari Activity type Higher or Secondary Education Establishments Administrative Contact Domenico Ribatti (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data DEL-PESTI CENTRUMKORHAZ-ORSZAGOS HEMATOLOGIAI ES INFEKTOLOGIAI INTEZET Hungary EU contribution € 144 000,00 Address Nagyvarad ter 1 1097 Budapest See on map Region Közép-Magyarország Budapest Budapest Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Tamás Masszi (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data VEREIN ZUR FOERDERUNG DER KREBSFORSCHUNG IN TIROL Austria EU contribution € 190 800,00 Address Innrain 66 6020 Innsbruck See on map Activity type Research Organisations Administrative Contact Richard Greil (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data KTB TUMORFORSCHUNGSGESELLSCHAFT MBH Germany EU contribution € 319 792,50 Address Breisacher strasse 117 79106 Freiburg See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Michael Kubbutat (Dr.) Links Contact the organisation Opens in new window Other funding No data VICHEM CHEMIE KUTATO KORLATOLT FELELOSSEGU TARSASAG Hungary EU contribution € 239 760,00 Address Viola utca 2 8200 Veszprem See on map Region Dunántúl Közép-Dunántúl Veszprém Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Zoltán Dobai (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data ONCOTYROL-CENTER FOR PERSONALIZED CANCER MEDICINE GMBH Austria EU contribution € 293 040,00 Address Karl kapferer strasse 5/3 6020 Innsbruck See on map Region Westösterreich Tirol Innsbruck Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Lukas A. Huber (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data PHARMA MAR SA Spain EU contribution € 239 880,00 Address Avda de los reyes 1 poligono industrial la mina colmenar viejo 28770 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Administrative Contact Elena Calleja (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data THE BINDING SITE GMBH Germany EU contribution € 37 200,00 Address Robert-bosch-straße 2a 68723 Schwetzingen See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Silvia Kirchner (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data CENTER OF EXCELLENCE IN MEDICINE AND IT GMBH Austria EU contribution € 194 000,00 Address Karl kapferer strasse 5 6020 Innsbruck See on map Region Westösterreich Tirol Innsbruck Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Manuela Bock Bartl (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data