Objective Multiple Myeloma (MM) is a currently incurable rare malignant plasma cell disease, which invariably relapses despite therapy. The objective of OVER-MYR is to understand the causes of drug resistance and relapse, develop novel strategies to overcome these, provide proof of principal for phase I/II trial, and thus impact on MM-patient’s survival.Currently-used drugs target both MM cells (MMC) and cells of the bone marrow (BM) microenvironment or ‘niche’ that are critical for supporting MMC survival, proliferation and growth. Since patients repeatedly relapse after such treatments, the following mechanisms of relapse are considered and need to be investigated:i) drugs have spared specific subclones or subpopulations of MMCii) drugs induce alterations in cells of the ‘niche’ that promote drug-resistance.OVER-MYR integrates a network of outstanding researchers from 6 EU countries with internationally recognized experience in clinics and human and animal models of MM, who will jointly:WP1: Study the molecular alterations in primary MM and environment cells in samples obtained from a large number of patients at treatment inclusion and relapse, using high throughput techniques.WP2: Implement in vitro and in vivo models of drug resistance to evaluate molecular and cellular mechanisms and compare their characteristics with drug resistant cells isolated from patients.Combined results of WP1 and WP2 will permit the identification of 10 prominent (altered) candidate genes involved in MM relapse. Changes in drug resistance, cell survival and proliferation will be assessed in WP2 by modulating the expression of the selected genes.WP3: Determine how cells from the niche alter their functions in the presence of drugs, and how drug-altered cells impact on MM cells during therapy.WP4: Screen chemical libraries for drugs active on generated sensitive cell lines, develop innovative inhibitors and provide proof of principle for a phase I/II trial Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug resistance Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2011.2.4.1-2 - Translational research on cancers with poor prognosis Call for proposal FP7-HEALTH-2011-two-stage See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator VRIJE UNIVERSITEIT BRUSSEL Address Pleinlaan 2 1050 Bruxelles / brussel Belgium See on map Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Activity type Higher or Secondary Education Establishments Administrative Contact Nik Claesen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (9) Sort alphabetically Sort by EU Contribution Expand all Collapse all INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution € 509 953,00 Address Rue de tolbiac 101 75654 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Vincent Boyer (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITATSKLINIKUM HEIDELBERG Germany EU contribution € 511 680,00 Address Im neuenheimer feld 672 69120 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Thorsten Brietz (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITY OF SOUTHAMPTON United Kingdom EU contribution € 324 564,00 Address Highfield SO17 1BJ Southampton See on map Region South East (England) Hampshire and Isle of Wight Southampton Activity type Higher or Secondary Education Establishments Administrative Contact Yan Qiao (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Netherlands EU contribution € 324 600,00 Address Meibergdreef 15 1105AZ Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Higher or Secondary Education Establishments Administrative Contact Frank J.M. Groen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data THE GARVAN INSTITUTE OF MEDICAL RESEARCH CHARITABLE INSTITUTION Australia EU contribution € 324 600,00 Address Victoria street 384 2010 Sydney nsw See on map Activity type Research Organisations Administrative Contact Cate Smith (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITA DEGLI STUDI DI BARI ALDO MORO Italy EU contribution € 250 800,00 Address Piazza umberto i 1 70121 Bari See on map Region Sud Puglia Bari Activity type Higher or Secondary Education Establishments Administrative Contact Vincenzo De Fazio (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data CELLZOME AG Participation ended Germany EU contribution € 0,00 Address Meyerhofstrasse 1 69117 Heidelberg See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Markus Reinhard (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data INSERM TRANSFERT SA France EU contribution € 176 988,00 Address 10 rue d'oradour-sur-glane - parisante campus 75015 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Louis Jammayrac (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data ONCODESIGN SA France EU contribution € 144 593,00 Address Rue jean mazen 20 21000 Dijon See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jan Hoflack (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
