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European Clinical trials in Rare Sarcomas within an integrated translational trial network

Objective

Sarcomas are rare malignant tumors, with an overall incidence of 6/105/year. Bone and soft tissue connective tissue tumours encompass more than 50 different rare histotypes and more than 150 different molecular subtypes. The incidence of individual rare sarcomas subtypes is often less than 0.5/105/year. Given sarcoma rarity as a group, but even more as individual entities, few prospective clinical trials testing local or systemic treatments have been performed in specific subtypes of sarcomas. Clinical trials in specific histological and molecular subtypes of sarcoma can only be performed through integrated clinical networks, centres of clinical excellence, supported by translational analysis. The drive for EUROSARC comes from the fact that sarcomas should now receive treatment adapted to histological and molecular subtypes and are ideal models to develop rational oncogene-targeted therapies. Trials based on selected molecular subtypes should now represent the standard approach to delineate novel treatments in individual disease subsets. They are also potential proof of concepts for first-in-class targeted treatment. EUROSARC aims at validating 1) novel local and systemic treatment strategies in localized phase, and 2) innovative targeted therapies in advanced phase based on the scientific understanding of molecular alterations driving the tumours thereby developing paradigm changing clinical research. The consortium builds on the successful co-ordination of scientific excellence of Conticanet and EuroBoNeT FP6 NoEs, where most partners were involved. The objective will be achieved through the development and conduct of 9 (2“Soft tissues” + 7“Bones”, 9 phase I/II and III) investigator-driven clinical trials in rare histological and molecular subtypes of sarcoma, through the establishment of an integrated consortium, gathering representatives of most European sarcoma groups, SME, all with proven track records of scientific and clinical excellence.

Call for proposal

FP7-HEALTH-2011-two-stage
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

UNIVERSITE LYON 1 CLAUDE BERNARD
Address
Boulevard Du 11 Novembre 1918 Num43
69622 Villeurbanne Cedex
France
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 680 563,28
Administrative Contact
Javier Olaiz (Dr.)

Participants (19)

ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 642 715,56
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Pancras Hogendoorn (Prof.)
INSTITUT GUSTAVE ROUSSY
France
EU contribution
€ 206 424,74
Address
Rue Camille Desmoulins 39
94805 Villejuif
Activity type
Research Organisations
Administrative Contact
Arnauld Forest (Mr.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 785 640,81
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stephen Conway (Dr.)
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI
Italy
EU contribution
€ 385 033,31
Address
Via Venezian 1
20133 Milan
Activity type
Research Organisations
Administrative Contact
Anabela Di Giovanni (Ms.)
ISTITUTO ORTOPEDICO RIZZOLI
Italy
EU contribution
€ 278 642,53
Address
Via Di Barbiano 1/10
40136 Bologna
Activity type
Research Organisations
Administrative Contact
Andrea Rizzi (Dr.)
INSTITUT BERGONIE
France
EU contribution
€ 430 629,36
Address
Cours De L Argonne 229
33076 Bordeaux Cedex
Activity type
Research Organisations
Administrative Contact
Jean-Michel Coindre (Prof.)
AZIENDA UNITA LOCALE SOCIO SANITARIA N 2 MARCA TREVIGIANA
Italy
EU contribution
€ 480 596,28
Address
Via Sant Ambrogio Di Fiera 37
31100 Treviso
Activity type
Research Organisations
Administrative Contact
Angelo Paolo Dei Tos (Dr.)
FUNDACION DE INVESTIGACION DEL CANCER DE LA UNIVERSIDAD DE SALAMANCA

Participation ended

Spain
EU contribution
€ 74 844,16
Address
Campus Miguel De Unamuno
37007 Salamanca
Activity type
Research Organisations
Administrative Contact
Enrique De Alava (Prof.)
MARIA SKLODOWSKA-CURIE MEMORIAL CANCER CENTER
Poland
EU contribution
€ 179 654
Address
Ul.w.k. Roentgena, 5
02781 Warzawa
Activity type
Research Organisations
Administrative Contact
Piotr Lukasz Rutkowski (Dr.)
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Germany
EU contribution
€ 191 535,70
Address
Seminarstrasse 2
69117 Heidelberg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Peter Hohenberger (Prof.)
Hospital Universitario Son Espases

Participation ended

Spain
EU contribution
€ 32 004
Address
Ctra. De Valldemossa
07120 Palma
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Mónica Castresana (Ms.)
EUROPEAN ORGANISATION FOR RESEARCH AND TREATMENT OF CANCER AISBL
Belgium
EU contribution
€ 616 906,67
Address
Avenue E. Mounier 83
1200 Brussels
Activity type
Research Organisations
Administrative Contact
Stephane Lejeune (Mr.)
SARCOMA PATIENTS EURONET EV
Germany
EU contribution
€ 58 200
Address
Untergasse 36
61200 Wolfersheim
Activity type
Other
Administrative Contact
Estelle Lecointe (Mrs.)
THE UNIVERSITY OF BIRMINGHAM
United Kingdom
EU contribution
€ 27 912
Address
Edgbaston
B15 2TT Birmingham
Activity type
Higher or Secondary Education Establishments
Administrative Contact
May Chung (Ms.)
OXFORD GENE TECHNOLOGY (OPERATIONS) Ltd
United Kingdom
EU contribution
€ 217 788,19
Address
Sandy Lane Begbroke Science Park Hirsch Building
OX5 1PF Yarnton Oxford
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Tony Lenhardt (Mr.)
LYON INGENIERIE PROJETS
France
EU contribution
€ 286 000
Address
Bd Du 11 Novembre 1918 43 L Atrium
69616 Villeurbanne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Javier Olaiz (Dr.)
FUNDACION DE LA SOCIEDAD ESPANOLA DE LA ONCOLOGIA MEDICA
Spain
EU contribution
€ 221 787,53
Address
Calle Velazquez 7 3
28001 Madrid
Activity type
Research Organisations
Administrative Contact
Maria Garcia (Mrs.)
SERVICIO ANDALUZ DE SALUD
Spain
EU contribution
€ 119 999,60
Address
Avenida De La Constitucion 18
41071 Sevilla
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Sophie Monteau (Mrs.)
Westfälische Wilhelms-Universität Münster
Germany
EU contribution
€ 36 954,28
Address
Schlossplatz 2
48149 Muenster
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Katharina Steinberg (Dr.)