Cel
Sarcomas are rare malignant tumors, with an overall incidence of 6/105/year. Bone and soft tissue connective tissue tumours encompass more than 50 different rare histotypes and more than 150 different molecular subtypes. The incidence of individual rare sarcomas subtypes is often less than 0.5/105/year. Given sarcoma rarity as a group, but even more as individual entities, few prospective clinical trials testing local or systemic treatments have been performed in specific subtypes of sarcomas. Clinical trials in specific histological and molecular subtypes of sarcoma can only be performed through integrated clinical networks, centres of clinical excellence, supported by translational analysis. The drive for EUROSARC comes from the fact that sarcomas should now receive treatment adapted to histological and molecular subtypes and are ideal models to develop rational oncogene-targeted therapies. Trials based on selected molecular subtypes should now represent the standard approach to delineate novel treatments in individual disease subsets. They are also potential proof of concepts for first-in-class targeted treatment. EUROSARC aims at validating 1) novel local and systemic treatment strategies in localized phase, and 2) innovative targeted therapies in advanced phase based on the scientific understanding of molecular alterations driving the tumours thereby developing paradigm changing clinical research. The consortium builds on the successful co-ordination of scientific excellence of Conticanet and EuroBoNeT FP6 NoEs, where most partners were involved. The objective will be achieved through the development and conduct of 9 (2“Soft tissues” + 7“Bones”, 9 phase I/II and III) investigator-driven clinical trials in rare histological and molecular subtypes of sarcoma, through the establishment of an integrated consortium, gathering representatives of most European sarcoma groups, SME, all with proven track records of scientific and clinical excellence.
Zaproszenie do składania wniosków
FP7-HEALTH-2011-two-stage
Zobacz inne projekty w ramach tego zaproszenia
System finansowania
CP-FP - Small or medium-scale focused research projectKoordynator
69622 Villeurbanne Cedex
Francja
Zobacz na mapie
Uczestnicy (19)
2333 ZA Leiden
Zobacz na mapie
94805 Villejuif
Zobacz na mapie
OX1 2JD Oxford
Zobacz na mapie
20133 Milan
Zobacz na mapie
40136 Bologna
Zobacz na mapie
33076 Bordeaux Cedex
Zobacz na mapie
31100 Treviso
Zobacz na mapie
Zakończenie uczestnictwa
37007 Salamanca
Zobacz na mapie
02-781 Warszawa
Zobacz na mapie
69117 Heidelberg
Zobacz na mapie
Zakończenie uczestnictwa
07120 Palma
Zobacz na mapie
1200 Bruxelles / Brussel
Zobacz na mapie
61200 Wolfersheim
Zobacz na mapie
B15 2TT Birmingham
Zobacz na mapie
OX5 PF OXFORD
Zobacz na mapie
69616 Villeurbanne
Zobacz na mapie
28001 MADRID
Zobacz na mapie
41071 Sevilla
Zobacz na mapie
48149 MUENSTER
Zobacz na mapie