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Biofilm Alliance

Objective

Infections by biofilm-forming microorganisms on indwelling medical devices such as catheters, prosthetic joints and internal fracture fixation devices pose a serious health threat. Overall, approximately 3% of all patients receiving such devices develop biofilm infections, with costs adding up to billions of Euro’s.
Current strategies to combat biofilms are based on conventional antibiotics. They often fail because 1) biofilms are difficult to penetrate, 2) micro-organisms in biofilms are resistant to most conventional antibiotics, 3) antibiotics cause release of pro-inflammatory microbial compounds, and 4) the locally available concentrations are too low.
The aim of BALI is to disrupt biofilm formation by a unique combination of Synthetic Antimicrobial Antibiofilm Peptides (SAAPs) with biofilm dispersing, microbicidal, and immune-orchestrating activity, incorporated in novel controlled release drug delivery formulations (PolyPid), for both prevention and treatment of biofilm infections. The recently developed SAAP OP-145, already tested in humans, will be the first candidate.
PolyPid, a unique polymer-lipid-based drug delivery platform will be tailored for coatings allowing prolonged and pre-determined release rates of SAAPs, to ensure the required local concentrations over a desired period. The coatings will be optimized in vitro and subsequently in mice and rabbit studies to prevent and treat biofilm infection. Finally a phase 1 study in patients with bone fracture fixation devices will be performed.
The novel SAAP-delivering PolyPid formulations can control biofilms and allows for treatment and management of infections, reducing infection rates of implanted medical devices. Patients relying on safe and effective medical devices thus will benefit strongly by reduction of infection frequencies. Besides improved health of EU citizens, the associated cost savings for hospitals and the economic benefits for the SMEs contribute to realization of EC policies

Field of science

  • /natural sciences/biological sciences/microbiology
  • /engineering and technology/materials engineering/coating and films

Call for proposal

FP7-HEALTH-2011-two-stage
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Address
Meibergdreef 15
1105AZ Amsterdam
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 618 845,96
Administrative Contact
Frank J.M. Groen

Participants (8)

POLYPID LTD
Israel
EU contribution
€ 576 871,69
Address
Hasadna St 11
82000 Raanana
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Amir Weisberg (Mr.)
AO-FORSCHUNGSINSTITUT DAVOS
Switzerland
EU contribution
€ 262 284,40
Address
Clavadelerstrasse 8
7270 Davos Platz
Activity type
Research Organisations
Administrative Contact
Rolf Keller (Mr.)
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 571 036,54
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Guillaine De Blécourt (Dr.)
AO DOCUMENTATION AND PUBLISHING FOUNDATION
Switzerland
EU contribution
€ 62 880,40
Address
Clavadelerstrasse 8
7270 Davos
Activity type
Research Organisations
Administrative Contact
Andreas Faeh (Mr.)
OESTERREICHISCHE AKADEMIE DER WISSENSCHAFTEN
Austria
EU contribution
€ 73 482,78
Address
Dr. Ignaz Seipel-platz 2
1010 Wien
Activity type
Research Organisations
Administrative Contact
Petra Auer-Nahold (Ms.)
MADAM THERAPEUTICS BV
Netherlands
EU contribution
€ 202 749,23
Address
Kade 1
2435 NM Zevenhove
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Remko Van Leeuwen (Dr.)
UNIVERSITAET GRAZ
Austria
EU contribution
€ 270 558,65
Address
Universitatsplatz 3
8010 Graz
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Schober-Trummler Caroline (Mrs.)
TOXI-COOP TOXIKOLOGIAI KUTATO KOZPONT ZARTKORUEN MUKODO RT
Hungary
EU contribution
€ 361 000
Address
Magyar Jakobinusok Tere 4/B 5.Em.2.
1122 Budapest
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Gábor Hirka (Dr.)