Objective Infections by biofilm-forming microorganisms on indwelling medical devices such as catheters, prosthetic joints and internal fracture fixation devices pose a serious health threat. Overall, approximately 3% of all patients receiving such devices develop biofilm infections, with costs adding up to billions of Euro’s.Current strategies to combat biofilms are based on conventional antibiotics. They often fail because 1) biofilms are difficult to penetrate, 2) micro-organisms in biofilms are resistant to most conventional antibiotics, 3) antibiotics cause release of pro-inflammatory microbial compounds, and 4) the locally available concentrations are too low.The aim of BALI is to disrupt biofilm formation by a unique combination of Synthetic Antimicrobial Antibiofilm Peptides (SAAPs) with biofilm dispersing, microbicidal, and immune-orchestrating activity, incorporated in novel controlled release drug delivery formulations (PolyPid), for both prevention and treatment of biofilm infections. The recently developed SAAP OP-145, already tested in humans, will be the first candidate.PolyPid, a unique polymer-lipid-based drug delivery platform will be tailored for coatings allowing prolonged and pre-determined release rates of SAAPs, to ensure the required local concentrations over a desired period. The coatings will be optimized in vitro and subsequently in mice and rabbit studies to prevent and treat biofilm infection. Finally a phase 1 study in patients with bone fracture fixation devices will be performed.The novel SAAP-delivering PolyPid formulations can control biofilms and allows for treatment and management of infections, reducing infection rates of implanted medical devices. Patients relying on safe and effective medical devices thus will benefit strongly by reduction of infection frequencies. Besides improved health of EU citizens, the associated cost savings for hospitals and the economic benefits for the SMEs contribute to realization of EC policies Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesengineering and technologymaterials engineeringcoating and filmsmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibioticsnatural sciencesbiological sciencesmicrobiology Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2011.2.3.1-5 - Development of tools to control microbial biofilms with relevance to clinical drug resistance Call for proposal FP7-HEALTH-2011-two-stage See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Address Meibergdreef 15 1105AZ Amsterdam Netherlands See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Higher or Secondary Education Establishments Administrative Contact Frank J.M. Groen Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (8) Sort alphabetically Sort by EU Contribution Expand all Collapse all POLYPID LTD Israel EU contribution € 576 871,69 Address Hasadna st 11 82000 Raanana See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Amir Weisberg (Mr.) Links Contact the organisation Opens in new window Other funding No data AO-FORSCHUNGSINSTITUT DAVOS Switzerland EU contribution € 262 284,40 Address Clavadelerstrasse 8 7270 Davos platz See on map Region Schweiz/Suisse/Svizzera Ostschweiz Graubünden / Grigioni / Grischun Activity type Research Organisations Administrative Contact Rolf Keller (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data ACADEMISCH ZIEKENHUIS LEIDEN Netherlands EU contribution € 571 036,54 Address Albinusdreef 2 2333 ZA Leiden See on map Region West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Activity type Higher or Secondary Education Establishments Administrative Contact Guillaine De Blécourt (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data AO Documentation and Publishing Foundation, Clinical Investigation and Documentation Switzerland EU contribution € 62 880,40 Address Clavadelerstrasse 7270 Davos See on map Activity type Research Organisations Administrative Contact Andreas Faeh (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data OESTERREICHISCHE AKADEMIE DER WISSENSCHAFTEN Austria EU contribution € 73 482,78 Address Dr. ignaz seipel-platz 2 1010 Wien See on map Region Ostösterreich Wien Wien Activity type Research Organisations Administrative Contact Petra Auer-Nahold (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data MADAM THERAPEUTICS BV Netherlands EU contribution € 202 749,23 Address Kade 1 2435 NM Zevenhove See on map Region West-Nederland Zuid-Holland Oost-Zuid-Holland Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Remko Van Leeuwen (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITAET GRAZ Austria EU contribution € 270 558,65 Address Universitatsplatz 3 8010 Graz See on map Region Südösterreich Steiermark Graz Activity type Higher or Secondary Education Establishments Administrative Contact Schober-Trummler Caroline (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data TOXI-COOP TOXIKOLOGIAI KUTATO KOZPONT ZARTKORUEN MUKODO RT Hungary EU contribution € 361 000,00 Address Magyar jakobinusok tere 4/b 5.em.2. 1122 Budapest See on map Region Közép-Magyarország Budapest Budapest Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Gábor Hirka (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
