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Genomic and lifestyle predictors of foetal outcome relevant to diabetes and obesity and their relevance to prevention strategies in South Asian peoples

Objective

Despite a strong genetic component to diabetes and obesity, the rapidly rising prevalence of these disorders is due to adaptation to a changing environment. The epicentre of the ‘diabetes epidemic’ is in South Asia and this is reflected in the migrant populations in Europe. Current prevention strategies are focused on adult life and target over-nutrition in high-risk adults. However, for many population groups across the globe, these strategies ignore many key principles that underlie the increasing global prevalence of these diseases. A substantial portion of the South Asian people, living in their home countries experience nutrition deprivation, while after migration to Europe, may encounter nutritional abundance resulting in imbalance during their lifecourse. These conditions are of particular importance during foetal and early developmental stages where environmental insults may interact with genetic risk to induce ‘foetal programming’ of adult metabolic disease. Few groups have targeted early life programming as an opportunity for the prevention of diabetes/obesity in childhood and subsequent adult life and there are limited guidelines on this topic. The proposed grant will bring together a unique group of investigators in South Asia (India, Bangladesh and Pakistan) and Europe (UK, Norway, Germany and Finland) with SMEs of complementary expertise (Germany and Spain) combining prevention strategies, state-of-the-art genomics, social sciences and public health that focus on these early life predictors of disease. The major objective behind this collaborative and multi-disciplinary approach is to combine knowledge from the work packages on lifestyle, nutrition and genomics to both inform public health policy through guideline development and design a large-scale pragmatic intervention to prevent the metabolic syndrome, obesity and diabetes in South Asian populations aimed at early life taking into account multi-generational effects.

Field of science

  • /medical and health sciences/clinical medicine/endocrinology/diabetes
  • /medical and health sciences/health sciences/public and environmental health
  • /social sciences
  • /medical and health sciences/health sciences/nutrition

Call for proposal

FP7-HEALTH-2011-two-stage
See other projects for this call

Funding Scheme

CP-FP-SICA - Small/medium-scale focused research project for specific cooperation actions dedicated to international cooperation partner countries(SICA)
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

QUEEN MARY UNIVERSITY OF LONDON
Address
327 Mile End Road
E1 4NS London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 842 092,94
Administrative Contact
Graham Hitman (Mr.)

Participants (15)

UNIVERSITETET I OSLO
Norway
EU contribution
€ 343 549,20
Address
Problemveien 5-7
0313 Oslo
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Knut Tore Stokke (Mr.)
KING EDWARD MEMORIAL HOSPITAL RESEARCH CENTRE
India
EU contribution
€ 140 404,80
Address
Sardar Moodliar Road, Rasta Peth
411011 Pune
Activity type
Research Organisations
Administrative Contact
Rajalakshmi Rangan (Ms.)
BAQAI MEDICAL UNIVERSITY
Pakistan
EU contribution
€ 80 403,60
Address
Plot 1 2 Ii B Block 2 Nazimabad 2
74600 Karachi
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Muhammad Abbasi (Dr.)
DIABETIC ASSOCIATION OF BANGLADESH - DAB
Bangladesh
EU contribution
€ 428 553,60
Address
Kazi Nazrul Islam Avenue 122
1000 Dhaka
Activity type
Research Organisations
Administrative Contact
Ak Azad Khan (Prof.)
PUBLIC HEALTH FOUNDATION OF INDIA
India
EU contribution
€ 148 425,60
Address
Isid Campus, 4Th Institutional Area, Vasant Kunj
110070 New Delhi
Activity type
Research Organisations
Administrative Contact
Amit Chaturvedi (Mr.)
UNIVERSITY OF SOUTHAMPTON
United Kingdom
EU contribution
€ 105 177,60
Address
Highfield
SO17 1BJ Southampton
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Caroline Fall (Prof.)
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER
United Kingdom
EU contribution
€ 16 202,40
Address
Keppel Street
WC1E 7HT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Greg Dow (Mr.)
THE UNIVERSITY OF EXETER
United Kingdom
EU contribution
€ 115 089,44
Address
The Queen's Drive Northcote House
EX4 4QJ Exeter
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tim Frayling (Prof.)
COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH
India
EU contribution
€ 159 098,40
Address
Anusandhan Bhawan, Rafi Marg 2
110001 New Dehli
Activity type
Research Organisations
Administrative Contact
Shankar Rao Jinde (Mr.)
TECHNISCHE UNIVERSITAET DRESDEN
Germany
EU contribution
€ 28 202,40
Address
Helmholtzstrasse 10
01069 Dresden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Beate Brenner (Mr.)
HELSINGIN YLIOPISTO
Finland
EU contribution
€ 16 203,20
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sanna Leppamaki (Ms.)
UNIVERSITY OF EAST LONDON
United Kingdom
EU contribution
€ 139 088,70
Address
University Way 4-6 Docklands Campus
E16 2RD London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Angela Harden (Prof.)
University College London
United Kingdom
EU contribution
€ 16 202,40
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Greta Borg-Carbott (Ms.)
INSTRUCT AG
Germany
EU contribution
€ 362 460,99
Address
Lindwurmstrasse 27
80337 Munchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Martin Adler (Mr.)
BAP HEALTH OUTCOMES RESEARCH SL

Participation ended

Spain
EU contribution
€ 58 176,73
Address
Calle Azcarraga 12
33600 Oviedo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Pablo Rebollo (Dr.)