Objective In acute neurodegenerative disorders, following a sudden insult, neurons are rapidly damaged and usually die but cellular loss can occur hours and days thereafter. These diseases cause massive morbidity and mortality and tremendous economic and societal burden, especially ischemic stroke, which is a leading cause of death and disability with no effective treatment to promote recovery. The brain responds to a stroke, i.e. occlusion of a cerebral artery, with an inflammatory process characterized by rapid activation of resident cells including microglia and astrocytes, production of proinflammatory mediators, and infiltration of various types of immune cells. Recent studies have suggested that the local inflammation is not only detrimental but can also be beneficial for the repair process. Our proposal unites 7 leading academic teams and 2 experienced SMEs and aims to develop a pre-clinical protocol for immunomodulation leading to enhancement of cellular plasticity and improved functional recovery in stroke patients. To achieve this goal we will study the temporal and spatial role of inflammatory cells in stroke-induced brain damage and determine the action of inflammatory cells in the activation and support of regenerative processes, including the formation of new neurons from endogenous and transplanted neural stem cells (NSCs). We will investigate the ability of transplanted NSCs to modulate the inflammatory response and to affect the characteristics of the stroke-induced lesion and subsequent recovery. The overriding social objective of our project is to develop a novel therapeutic strategy which will shorten the recovery phase, minimize the motor impairments, and improve the patients’quality of life after stroke. Fields of science social sciencessociologydemographymortalitymedical and health sciencesbasic medicineimmunologymedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesbasic medicineneurologystroke Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2011.2.2.1-2 - Understanding the role of neuroinflammation in neurodegenerative diseases Call for proposal FP7-HEALTH-2011-two-stage See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator LUNDS UNIVERSITET EU contribution € 2 132 786,00 Address Paradisgatan 5c 22100 Lund Sweden See on map Region Södra Sverige Sydsverige Skåne län Activity type Higher or Secondary Education Establishments Administrative Contact Zaal Kokaia (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (9) Sort alphabetically Sort by EU Contribution Expand all Collapse all WEIZMANN INSTITUTE OF SCIENCE Israel EU contribution € 1 594 223,00 Address HERZL STREET 234 7610001 Rehovot See on map Activity type Higher or Secondary Education Establishments Administrative Contact Talia Tzahor (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITA VITA-SALUTE SAN RAFFAELE Italy EU contribution € 1 364 200,00 Address VIA OLGETTINA 58 20132 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Higher or Secondary Education Establishments Administrative Contact Maria Rosa Pedrazzi (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Germany EU contribution € 1 455 945,00 Address HOFGARTENSTRASSE 8 80539 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Mathias Hoehn (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAT ZURICH Switzerland EU contribution € 1 461 540,00 Address RAMISTRASSE 71 8006 Zurich See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Administrative Contact Ines Scholz (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ST GEORGE'S HOSPITAL MEDICAL SCHOOL United Kingdom EU contribution € 1 431 600,00 Address CRANMER TERRACE SW17 0RE London See on map Region London Inner London — West Wandsworth Activity type Higher or Secondary Education Establishments Administrative Contact Claudia Eder (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data GOETEBORGS UNIVERSITET Sweden EU contribution € 1 461 510,00 Address VASAPARKEN 405 30 Goeteborg See on map Region Södra Sverige Västsverige Västra Götalands län Activity type Higher or Secondary Education Establishments Administrative Contact Milos Pekny (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data PRONEURON BIOTHECHNOLOGIES (ISRAEL) LTD Participation ended Israel EU contribution No data Address AHUZA STREET 45 43208 RAANANA See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Eti Yoles (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data GEMAC France EU contribution € 587 378,00 Address LIEU DIT BERGANTON 33127 SAINT JEAN D ILLAC See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Marie Claire Goichon (Dr.) Links Contact the organisation Opens in new window Total cost No data IMMUNOBRAIN LTD Israel EU contribution € 499 980,00 Address PEKRIS STREET 3 REHOVOT See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Eti Yoles (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
