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Targeting Brain Inflammation For Improved Functional Recovery in Acute Neurodegenerative Disorders

Objective

In acute neurodegenerative disorders, following a sudden insult, neurons are rapidly damaged and usually die but cellular loss can occur hours and days thereafter. These diseases cause massive morbidity and mortality and tremendous economic and societal burden, especially ischemic stroke, which is a leading cause of death and disability with no effective treatment to promote recovery. The brain responds to a stroke, i.e. occlusion of a cerebral artery, with an inflammatory process characterized by rapid activation of resident cells including microglia and astrocytes, production of proinflammatory mediators, and infiltration of various types of immune cells. Recent studies have suggested that the local inflammation is not only detrimental but can also be beneficial for the repair process. Our proposal unites 7 leading academic teams and 2 experienced SMEs and aims to develop a pre-clinical protocol for immunomodulation leading to enhancement of cellular plasticity and improved functional recovery in stroke patients. To achieve this goal we will study the temporal and spatial role of inflammatory cells in stroke-induced brain damage and determine the action of inflammatory cells in the activation and support of regenerative processes, including the formation of new neurons from endogenous and transplanted neural stem cells (NSCs). We will investigate the ability of transplanted NSCs to modulate the inflammatory response and to affect the characteristics of the stroke-induced lesion and subsequent recovery. The overriding social objective of our project is to develop a novel therapeutic strategy which will shorten the recovery phase, minimize the motor impairments, and improve the patients’quality of life after stroke.

Call for proposal

FP7-HEALTH-2011-two-stage
See other projects for this call

Coordinator

MAX IV Laboratory, Lund University
Address
Paradisgatan 5C
22100 Lund
Sweden
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 132 786
Administrative Contact
Zaal Kokaia (Prof.)

Participants (9)

WEIZMANN INSTITUTE OF SCIENCE
Israel
EU contribution
€ 1 594 223
Address
Herzl Street 234
7610001 Rehovot
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Talia Tzahor (Ms.)
UNIVERSITA VITA-SALUTE SAN RAFFAELE
Italy
EU contribution
€ 1 364 200
Address
Via Olgettina 58
20132 Milano
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maria Rosa Pedrazzi (Dr.)
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 1 455 945
Address
Hofgartenstrasse 8
80539 Munchen
Activity type
Research Organisations
Administrative Contact
Mathias Hoehn (Prof.)
University of Zurich
Switzerland
EU contribution
€ 1 461 540
Address
Ramistrasse 71
8006 Zurich
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ines Scholz (Ms.)
ST GEORGE'S HOSPITAL MEDICAL SCHOOL
United Kingdom
EU contribution
€ 1 431 600
Address
Cranmer Terrace
SW17 0RE London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Claudia Eder (Dr.)
GOETEBORGS UNIVERSITET
Sweden
EU contribution
€ 1 461 510
Address
Vasaparken
405 30 Goeteborg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Milos Pekny (Prof.)
PRONEURON BIOTHECHNOLOGIES (ISRAEL) LTD

Participation ended

Israel
Address
Ahuza Street 45
43208 Raanana
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Eti Yoles (Dr.)
GEMAC
France
EU contribution
€ 587 378
Address
Lieu Dit Berganton
33127 Saint Jean D Illac
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Marie Claire Goichon (Dr.)
IMMUNOBRAIN LTD
Israel
EU contribution
€ 499 980
Address
Pekris Street 3
Rehovot
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Eti Yoles (Dr.)