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Biomimetic process design for tissue regeneration:
from bench to bedside via in silico modelling

Objective

"Tissue engineering (TE), the interdisciplinary field combining biomedical and engineering sciences in the search for functional man-made organ replacements, has key issues with the quantity and quality of the generated products. Protocols followed in the lab are mainly trial and error based, requiring a huge amount of manual interventions and lacking clear early time-point quality criteria to guide the process. As a result, these processes are very hard to scale up to industrial production levels. BRIDGE aims to fortify the engineering aspects of the TE field by adding a higher level of understanding and control to the manufacturing process (MP) through the use of in silico models. BRIDGE will focus on the bone TE field to provide proof of concept for its in silico approach.

The combination of the applicant's well-received published and ongoing work on a wide range of modelling tools in the bone field combined with the state-of-the-art experimental techniques present in the TE lab of the additional participant allows envisaging following innovation and impact:
1. proof-of-concept of the use of an in silico blue-print for the design and control of a robust modular TE MP;
2. model-derived optimised culture conditions for patient derived cell populations increasing modular robustness of in vitro chondrogenesis/endochondral ossification;
3. in silico identification of a limited set of in vitro biomarkers that is predictive of the in vivo outcome;
4. model-derived optimised culture conditions increasing quantity and quality of the in vivo outcome of the TE MP;
5. incorporation of congenital defects in the in silico MP design, constituting a further validation of BRIDGE’s in silico approach and a necessary step towards personalised medical care.

We believe that the systematic – and unprecedented – integration of (bone) TE and mathematical modelling, as proposed in BRIDGE, is required to come to a rationalized, engineering approach to design and control bone TE MPs."

Field of science

  • /medical and health sciences/medical biotechnology/tissue engineering

Call for proposal

ERC-2011-StG_20101014
See other projects for this call

Funding Scheme

ERC-SG - ERC Starting Grant

Host institution

UNIVERSITE DE LIEGE
Address
Place Du 20 Aout 7
4000 Liege
Belgium
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 487 760
Principal investigator
Liesbet Geris (Prof.)
Administrative Contact
Isabelle Halleux (Dr.)

Beneficiaries (2)

UNIVERSITE DE LIEGE
Belgium
EU contribution
€ 487 760
Address
Place Du 20 Aout 7
4000 Liege
Activity type
Higher or Secondary Education Establishments
Principal investigator
Liesbet Geris (Prof.)
Administrative Contact
Isabelle Halleux (Dr.)
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 703 680
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stijn Delauré (Dr.)