Objetivo "Protein kinases represent key signal transduction components transferring signals to their effectors by phosphorylation. Among other important functions, MAPK-dependent signal transduction is principally required to control inflammation and metabolism in vertebrates. However, chronic MAPK signaling in response to environmental stress contributes to the development of metabolic and inflammatory diseases.While most studies investigated functions of p38α of the p38 MAPK family, we have recently identified first non-redundant in vivo functions for p38δ. We found that p38δ regulates glucose homeostasis by controlling insulin secretion from pancreatic β cells and more recently that p38δ is pivotal in regulation of neutrophil-mediated inflammation. At the molecular level, both functions are dependent on Protein Kinase D1 (PKD1) activity, the latter of which, we identified as a direct and negatively regulated target of p38δ. Overall, our recent work describes a new signaling axis that may be important in diabetes mellitus and inflammatory diseases, respectively.The future core activity of my laboratory is directed towards elucidation of particular roles of p38δ and PKD1 downstream targets in neutrophils and β cells. We also aim at finding common upstream signaling mechanisms that converge in p38δ-PKD1 signaling. Finally, we will explore newly discovered potential metabolic processes that are regulated by this signaling module. This biased research will be complemented by a more comprehensive proteomic screening approach in liver focusing on basic metabolic adaption in response to fasting and feeding. While, protein phosphorylation is widely explored in this context, we will globally screen for ubiquitination of proteins that recently emerged as a key event in cellular signaling.Our work will hopefully lead to the discovery of novel and important cellular and molecular mechanisms in metabolism and inflammation with relevant implications in related human disorders." Ámbito científico medical and health scienceshealth sciencesinflammatory diseasesnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesbasic medicinephysiologyhomeostasis Programa(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) ERC-SG-LS4 - ERC Starting Grant - Physiology, Pathophysiology and Endocrinology Convocatoria de propuestas ERC-2011-StG_20101109 Consulte otros proyectos de esta convocatoria Régimen de financiación ERC-SG - ERC Starting Grant Institución de acogida CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE Aportación de la UE € 1 499 360,00 Dirección Rue Laurent Fries 1 67404 Illkirch Graffenstaden Francia Ver en el mapa Región Grand Est Alsace Bas-Rhin Tipo de actividad Research Organisations Investigador principal Romeo Ricci (Prof.) Contacto administrativo Steve Brooks (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Beneficiarios (1) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE Francia Aportación de la UE € 1 499 360,00 Dirección Rue Laurent Fries 1 67404 Illkirch Graffenstaden Ver en el mapa Región Grand Est Alsace Bas-Rhin Tipo de actividad Research Organisations Investigador principal Romeo Ricci (Prof.) Contacto administrativo Steve Brooks (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos