Objective
Resolution of inflammation is a key determinant of pathology, and an active process which involves diverse pathways and molecules. The general objective of the TIMER Consortium is to identify and validate new molecules involved in the resolution of inflammation as a basis for the development of innovative therapeutic strategies in chronic inflammatory and autoimmune diseases. The project will involve discovery of new natural or synthetic “pro-resolving” molecules for plant and animals and investigation on endogenous inflammation “pro-resolving” mechanisms identified by various partners of the Consortium, including atypical chemokine receptors, decoy receptors, and microRNA. Tapping resources of natural compounds will be a major thrust. Efforts will be mainly focused on the regulation by “pro-resolving” agents on two molecular systems of key relevance in inflammation: the chemokine system, which regulates recruitment, permanence and egress of leukocyte in tissues; and the TLR/IL-1R system, which is central for the activation of infiltrating leukocytes.
To this purpose, the project will capitalize on, and bring added value to a strong tradition of the Consortium in the fields of: leukocyte recruitment and activation; negative regulators of inflammation; industrial-academic collaboration; identification and characterization of innovative inhibitors of natural origin; European-Brazilian collaboration.
Fields of science
Topic(s)
Call for proposal
FP7-HEALTH-2011-single-stage
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Funding Scheme
CP-FP - Small or medium-scale focused research projectCoordinator
20089 Rozzano
Italy
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Participants (12)
Participation ended
67100 L'Aquila
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31270 901 Belo Horizonte Minas Gerais
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05508 900 Sao Paulo Sp
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21040 900 Rio De Janeiro
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6500 Bellinzona
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G12 8QQ Glasgow
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Participation ended
6934 Bioggio
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D02 CX56 DUBLIN 2
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Participation ended
1202 Geneve
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53100 Siena
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1228 Plan Les Ouates Geneve
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20122 Milano
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