Skip to main content

Targeting Src-family tyrosine kinases in chronic autoimmune and inflammatory diseases

Objective

The project aims to develop novel inhibitors of chronic autoimmune and inflammatory diseases by targeting members of the Src tyrosine kinase family. Src-family kinases have recently emerged as major therapeutic targets in malignant diseases but their suitability as potential targets of inflammatory diseases has not yet recieved widespread acceptance. On the other hand, members of the applicant consortium have recently obtained genetic evidence showing that myeloid Src-family kinases (Hck, Fgr and Lyn) are indispensable for murine models of autoimmune inflammatory diseases such as rheumatoid arthritis or blistering skin diseases. They also developed a number of novel Src-family kinase inhibitors that also block inflammation-related in vitro leukocyte functions. The applicants will test and further develop novel Src-family kinase inhibitors as anti-inflammatory compounds, using several in vitro and in vivo inflammation assays to optimize the structure of the selected molecules. They will also test whether Src-family inhibitors already in clinical use in oncology patients also inhibit inflammatory processes. Finally, they will use Src-family kinase-deficient mice in several inflammation models to test the role of those kinases in more detail and to provide further reference information for the consortium's preclinical drug development activity. The selected inhibitors and mutant mice will be pre-screened using various inflammation-related in vitro leukocyte functions and short-term in vivo inflammation models, and then analyzed in detail using a number of in vivo mouse models of chronic autoimmune and inflammatory diseases. The project is expected to result in development of novel preclinical drug candidates against chronic autoimmune and inflammatory disease with novel mechanism of action, as well as novel knowledge on the role of Src-family kinases in inflammatory diseases. The project will be performed in close cooperation between European and Brazilian scientists.

Call for proposal

FP7-HEALTH-2011-single-stage
See other projects for this call

Coordinator

SEMMELWEIS EGYETEM
Address
Ulloi Utca 26
1085 Budapest
Hungary
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 551 962
Administrative Contact
Miklós Tóth (Prof.)

Participants (10)

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 493 280
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Markus Sperandio (Prof.)
UNIVERSITA DEGLI STUDI DI VERONA
Italy
EU contribution
€ 296 082
Address
Via Dell Artigliere 8
37129 Verona
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Enrico Maria Cazzaroli (Dr.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 295 950
Address
Rue Michel Ange 3
75794 Paris
Activity type
Other
Administrative Contact
Armelle Barelli (Ms.)
VICHEM CHEMIE KUTATO KFT
Hungary
EU contribution
€ 296 010
Address
Hermann Otto Utca 15
1022 Budapest
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Zoltán Dobai (Mr.)
UNIVERSITAETSKLINIKUM FREIBURG
Germany
EU contribution
€ 246 228
Address
Hugstetter Strasse 49
79106 Freiburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jürgen Dreyer (Mr.)
UNIVERSIDADE FEDERAL DO RIO DE JANEIRO
Brazil
EU contribution
€ 246 822
Address
Av Brigadeiro Trompowski Sn 2
21941 590 Rio De Janeiro
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Marta Farias (Ms.)
BIOMEDCODE ELLAS ANONIMI ETERIA EPISTIMONIKIS KAI TEXNOLOGIKIS EREVNAS KAI EMBORIKIS EKMETALLEFSIS EPHARMOGON IATRIKIS
Greece
EU contribution
€ 177 570
Address
Alexander Fleming Street 34
16672 Vari
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Piyi Papadaki (Dr.)
AMBIOTIS
France
EU contribution
€ 147 978
Address
Canal Biotech 2 3 Rue Des Satellites
31400 Toulouse
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Marc Dubourdeau (Dr.)
FUNDACAO OSWALDO CRUZ
Brazil
EU contribution
€ 147 978
Address
Avenida Brasil 4365
21040 900 Rio De Janeiro
Activity type
Research Organisations
Administrative Contact
Adolfo Horácio Chorny (Dr.)
ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU
Italy
EU contribution
€ 100 000
Address
Via Fiorentina 151
53100 Siena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Cristiana Tozzi (Dr.)