Objective The project aims to develop novel inhibitors of chronic autoimmune and inflammatory diseases by targeting members of the Src tyrosine kinase family. Src-family kinases have recently emerged as major therapeutic targets in malignant diseases but their suitability as potential targets of inflammatory diseases has not yet recieved widespread acceptance. On the other hand, members of the applicant consortium have recently obtained genetic evidence showing that myeloid Src-family kinases (Hck, Fgr and Lyn) are indispensable for murine models of autoimmune inflammatory diseases such as rheumatoid arthritis or blistering skin diseases. They also developed a number of novel Src-family kinase inhibitors that also block inflammation-related in vitro leukocyte functions. The applicants will test and further develop novel Src-family kinase inhibitors as anti-inflammatory compounds, using several in vitro and in vivo inflammation assays to optimize the structure of the selected molecules. They will also test whether Src-family inhibitors already in clinical use in oncology patients also inhibit inflammatory processes. Finally, they will use Src-family kinase-deficient mice in several inflammation models to test the role of those kinases in more detail and to provide further reference information for the consortium's preclinical drug development activity. The selected inhibitors and mutant mice will be pre-screened using various inflammation-related in vitro leukocyte functions and short-term in vivo inflammation models, and then analyzed in detail using a number of in vivo mouse models of chronic autoimmune and inflammatory diseases. The project is expected to result in development of novel preclinical drug candidates against chronic autoimmune and inflammatory disease with novel mechanism of action, as well as novel knowledge on the role of Src-family kinases in inflammatory diseases. The project will be performed in close cooperation between European and Brazilian scientists. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health sciencesclinical medicinerheumatologymedical and health scienceshealth sciencesinflammatory diseasesmedical and health sciencesclinical medicineoncology Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2011.1.4-5 - New therapeutic approaches in chronic inflammatory and autoimmune diseases Call for proposal FP7-HEALTH-2011-single-stage See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator SEMMELWEIS EGYETEM Address Ulloi utca 26 1085 Budapest Hungary See on map Region Közép-Magyarország Budapest Budapest Activity type Higher or Secondary Education Establishments Administrative Contact Miklós Tóth (Prof.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 551 962,00 Participants (10) Sort alphabetically Sort by EU Contribution Expand all Collapse all LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Germany EU contribution € 493 280,00 Address Geschwister scholl platz 1 80539 Muenchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Markus Sperandio (Prof.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITA DEGLI STUDI DI VERONA Italy EU contribution € 296 082,00 Address Via dell artigliere 8 37129 Verona See on map Region Nord-Est Veneto Verona Activity type Higher or Secondary Education Establishments Administrative Contact Enrico Maria Cazzaroli (Dr.) Links Contact the organisation Opens in new window Website Opens in new window CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France EU contribution € 295 950,00 Address Rue michel ange 3 75794 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Armelle Barelli (Ms.) Links Contact the organisation Opens in new window Website Opens in new window VICHEM CHEMIE KUTATO KORLATOLT FELELOSSEGU TARSASAG Hungary EU contribution € 296 010,00 Address Viola utca 2 8200 Veszprem See on map Region Dunántúl Közép-Dunántúl Veszprém Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Zoltán Dobai (Mr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITAETSKLINIKUM FREIBURG Germany EU contribution € 246 228,00 Address Hugstetter strasse 49 79106 Freiburg See on map Region Baden-Württemberg Freiburg Freiburg im Breisgau, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Jürgen Dreyer (Mr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSIDADE FEDERAL DO RIO DE JANEIRO Brazil EU contribution € 246 822,00 Address Av brigadeiro trompowski sn 2 21941 590 Rio de janeiro See on map Activity type Higher or Secondary Education Establishments Administrative Contact Marta Farias (Ms.) Links Contact the organisation Opens in new window BIOMEDCODE ELLAS ANONIMI ETERIA EPISTIMONIKIS KAI TEXNOLOGIKIS EREVNAS KAI EMBORIKIS EKMETALLEFSIS EPHARMOGON IATRIKIS Greece EU contribution € 177 570,00 Address Alexander fleming street 34 16672 Vari See on map Region Αττική Aττική Ανατολική Αττική Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Piyi Papadaki (Dr.) Links Contact the organisation Opens in new window Website Opens in new window AMBIOTIS France EU contribution € 147 978,00 Address Canal biotech 2 3 rue des satellites 31400 Toulouse See on map Region Occitanie Midi-Pyrénées Haute-Garonne Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Marc Dubourdeau (Dr.) Links Contact the organisation Opens in new window Website Opens in new window FUNDACAO OSWALDO CRUZ Brazil EU contribution € 147 978,00 Address Avenida brasil 4365 21040 900 Rio de janeiro See on map Activity type Research Organisations Administrative Contact Adolfo Horácio Chorny (Dr.) Links Contact the organisation Opens in new window Website Opens in new window ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU Italy EU contribution € 100 000,00 Address Via fiorentina 151 53100 Siena See on map Region Centro (IT) Toscana Siena Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Cristiana Tozzi (Dr.) Links Contact the organisation Opens in new window Website Opens in new window
