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A BLUEPRINT of Haematopoietic Epigenomes

Objectif

In response to the call for a high impact initiative on the human epigenome, the BLUEPRINT Consortium has been formed with the aim of generating at least 100 reference epigenomes and studying them to advance and exploit knowledge of the underlying biological processes and mechanisms in health and disease. BLUEPRINT will focus on distinct types of haematopoietic cells from healthy individuals and on their malignant leukaemic counterparts. Reference epigenomes will be generated by state-of-the-art technologies from highly purified cells for a comprehensive set of epigenetic marks in accordance with quality standards set by IHEC. This resource-generating activity will be conducted at dedicated centres to be complemented by confederated hypothesis-driven research into blood-based diseases, including common leukaemias and autoimmune disease (T1D), by epigenetic targets and compound identification, and by discovery and validation of epigenetic markers for diagnostic use. By focussing on 100 samples of known genetic variation BLUEPRINT will complete an epigenome-wide association study, maximizing the biomedical relevance of the reference epigenomes. Key to the success of BLUEPRINT will be the integration with other data sources (i.e. ICGC, 1000 genomes and ENCODE), comprehensive bioinformatic analysis, and user-friendly dissemination to the wider scientific community. The involvement of innovative companies will energize epigenomic research in the private sector by creating new targets for compounds and the development of smart technologies for better diagnostic tests. BLUEPRINT will outreach through a network of associated members and form critical alliances with leading networks in genomics and epigenomics within Europe and worldwide. Through its interdisciplinarity and scientific excellence combined with its strong commitment to networking, training and communication BLUEPRINT strives to become the cornerstone of the EU contribution to IHEC.

Champ scientifique

Programme(s)

Thème(s)

Appel à propositions

FP7-HEALTH-2011-single-stage
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Régime de financement

CP-IP - Large-scale integrating project

Coordinateur

STICHTING RADBOUD UNIVERSITEIT
Contribution de l’UE
€ 5 108 118,63
Adresse
HOUTLAAN 4
6525 XZ Nijmegen
Pays-Bas

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Région
Oost-Nederland Gelderland Arnhem/Nijmegen
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Marion Bussemakers (Dr.)
Liens
Coût total
Aucune donnée

Participants (44)

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Dernière mise à jour: 30 Mars 2022

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Permalink: https://cordis.europa.eu/project/id/282510/fr

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