Objective The four-year MICRO-THERAPY is a fully integrated interdisciplinary proposal which will develop a new area of competence in the three partners, Liverpool John Moores University, University of Rennes1 and ManRos Therapeutics. It brings together a powerful set of partners covering fully the three key aspects - microwave engineering, chemistry and biology to create new technology and sustainable technical and scientific expertise applicable to the bio-pharmaceutical industry. The proposed research programme is unique in terms of generating a tuneable, multipurpose, microwave, continuous, atmospheric pressure, flow reactor for the efficient conduct of various chemical reactions for the synthesis of Leucettamines to be used against Alzheimer’s disease. Unlike the restricted batch reactors a continuous microwave reactor has the potential to operate at high production rates simply by virtue of offering continuous throughput and, more significantly, by being easy to replicate allowing scale up the process for bulk production at commercial rates. In addition the system will operate for the first time with tuneable frequency microwaves in the range 2.45 – 8GHz in order to optimise the process to produce higher yields with reduced separation costs. This is unlike current microwave synthesis where the source is only operated at one fixed frequency of 2.45GHz and is therefore not necessary have the optimum operating frequency to suit various chemicals reactions at different temperatures. The timeliness of MICRO-THERAPY is a response to demand for new ways to produce chemicals for the therapeutic activities against Alzheimer’s disease. However, such a reactor also has scope fore much wider applicationThe main objectives of this project are to:1. To use the project to develop new cross-disciplinary expertise through the recruitment of experienced researchers to work particularly at LJMU and UR1, but also incorporating expertise at MRT thereby providing new training and development opportunities for young and experienced researchers at the partners, blending an expanding knowledge base and unique skills to produce key proficiencies.2. To specifically develop a multipurpose prototype reactor for the synthesis of bulk quantities of chemicals on a continuous basis by using novel atmospheric pressure, continuous microwave flow reactor.3. To select the reaction time, flow rate, microwave power and frequency within the operating range 2.45 to 8GHz to produce chemicals with high yield, low waste and using low power in comparison with the conventional techniques. Fields of science medical and health sciencesbasic medicineneurologydementiaalzheimernatural sciencesearth and related environmental sciencesatmospheric sciencesmeteorologyatmospheric pressurenatural scienceschemical sciences Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2011-IAPP - Marie Curie Action: "Industry-Academia Partnerships and Pathways" Call for proposal FP7-PEOPLE-2011-IAPP See other projects for this call Funding Scheme MC-IAPP - Industry-Academia Partnerships and Pathways (IAPP) Coordinator LIVERPOOL JOHN MOORES UNIVERSITY Address Rodney street 2 egerton court L3 5UX Liverpool United Kingdom See on map Region North West (England) Merseyside Liverpool Activity type Higher or Secondary Education Establishments Administrative Contact Ian Pennington (Prof.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (2) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITE DE RENNES I France EU contribution € 196 766,00 Address Rue du thabor 2 35065 Rennes cedex See on map Region Bretagne Bretagne Ille-et-Vilaine Activity type Higher or Secondary Education Establishments Administrative Contact Yolaine Bompays (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data ManRos Therapeutics France EU contribution € 91 317,00 Address Rue bir hakeim 16 29680 Roscoff See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Laurent Meijer (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
