Objective The primary aim of this project is to develop novel bacteriophage based strategies to combat Proteus mirabilis catheter associated urinary tract infection (CAUTI), a prevalent health-care associated infection for which there are currently no effective countermeasures. Indwelling urethral catheters (IUC) are the most commonly deployed medical devices, it is estimated that ~100 million IUC are used annually in healthcare systems globally, which equates to ~190 catheterisations per minute. However, IUC are vulnerable to infection, undermining their utility, jeopardising patient welfare and posing a substantial economic burden on healthcare systems. Over 40% of CAUTIs may be attributed to P. mirabilis, which poses particular problems in the care of catheterised patients. P. mirabilis causes encrustation and blockage of catheters, leading to serious complications such as pyelonephritis, septicaemia and shock. It is difficult to eliminate from the catheterised urinary tract, even after the catheter is removed, and often causes chronic infection recalcitrant to conventional antibiotic therapy. Given the prolific use of IUC and corresponding prevalence of CAUTIs in healthcare systems across the world, development of bacteriophage based strategies for control of CAUTIs would open a niche in a global market that is projected to reach an annual value of €2 billion by 2015. Fields of science medical and health sciencesclinical medicineurology Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2011-IAPP - Marie Curie Action: "Industry-Academia Partnerships and Pathways" Call for proposal FP7-PEOPLE-2011-IAPP See other projects for this call Funding Scheme MC-IAPP - Industry-Academia Partnerships and Pathways (IAPP) Coordinator UNIVERSITY OF BRIGHTON EU contribution € 371 007,00 Address LEWES ROAD MITHRAS HOUSE BN2 4AT Brighton United Kingdom See on map Region South East (England) Surrey, East and West Sussex Brighton and Hove Activity type Higher or Secondary Education Establishments Administrative Contact Brian Jones (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (3) Sort alphabetically Sort by EU Contribution Expand all Collapse all BIOCONTROL LIMITED United Kingdom EU contribution € 195 525,00 Address GEORGE STREET 79 PO33 2JF ISLE OF WIGHT See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Mark Enright (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK Ireland EU contribution € 388 826,00 Address WESTERN ROAD T12 YN60 Cork See on map Region Ireland Southern South-East Activity type Higher or Secondary Education Establishments Administrative Contact David O'connell (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data TEAGASC - AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY Ireland EU contribution € 122 956,00 Address Oak Park R93 Carlow See on map Region Ireland Southern South-East Activity type Higher or Secondary Education Establishments Administrative Contact Mary O'brien (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data