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Code-engineered new-to-nature microbial cell factories for novel and safety enhanced bio-production

Objective

The concept of METACODE is to preform genetic code engineering in microbial strains with parallel recruitment of novel bio-orthogonal chemistries for mass production of desired protein/peptide based products. In combination with computational and classical chemical synthetic approaches as well as chemo-informatics, enzyme guided evolution, synthetic metabolism, and directed evolution of microbial strains, artificial industrial microbial strains will be designed. This will enable the access to genetically robust and safe strains with added/novel functionalities and topologies from renewable resources. These strains will be characterized with alternative reading of the genetic code (genetic firewall) and with predetermined chemistries (metathesis), as well as necessary robustness for efficient industrial use.

Call for proposal

FP7-KBBE-2011-5
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Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

TECHNISCHE UNIVERSITAT BERLIN
Address
Strasse Des 17 Juni 135
10623 Berlin
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 898 809
Administrative Contact
Silke Hönert (Ms.)

Participants (7)

Isthmus
France
EU contribution
€ 343 992
Address
Rue Saint Amand 31
75015 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Pierre Dedenys (Mr.)
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
EU contribution
€ 499 237
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sven Panke (Prof.)
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 250 000
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sarah Malevé (Ms.)
UNIVERSITAT BASEL
Switzerland
EU contribution
€ 249 600
Address
Petersplatz 1
4051 Basel
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Thomas Ward (Prof.)
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
EU contribution
€ 249 780
Address
Rue Leblanc 25
75015 Paris 15
Activity type
Research Organisations
Administrative Contact
Mathilde Suret (Ms.)
MOLECULAR NETWORKS GMBH COMPUTERCHEMIE
Germany
EU contribution
€ 241 200
Address
Neumeyerstr 28-34
90411 Nurnberg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Johann Gasteiger (Prof.)
BIOFACTION KG
Austria
EU contribution
€ 264 320
Address
Kundmanngasse 39/12
1030 Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Markus Schmidt (Dr.)